摘要
银杏内酯是银杏叶提取物的主要组成部分,是银杏特有的化学成分,具有多种生物活性,但由于其含量低,研究较少。本文综述了银杏萜类内酯的提取方法、分离纯化方法,以及检测方法。通过选取合适的溶剂和提取方法,综合柱色谱分离、溶剂萃取法等分离操作,可以得到银杏内酯含量较高的提取物,再采用结晶法,高速逆流色谱等方法,可以得到更高纯度的银杏内酯,甚至可以得到银杏内酯单体,对银杏药物的开发有重大意义。
Ginkgolides are the main and special ingredients of extracts of Ginkgo biloba leaves.And ginkgolides have many kinds of biological activities.There are little research on ginkgolides because of a smaller amount of ginkgolides in Ginkgo biloba leaves.In this paper,a comprehensive descriptior is made of the extraction,separation,purification and detection methods of ginkgolides.The high purity of ginkgolides could be obtained by choosing suitable solvents and extraction methods with appropriate separation ways,such as column chromatography and solvent extraction method.While higher purity of ginkgolides,even monomers of ginkgolides were obtained by crystallization process,high-speed countercurrent chromatography,which is important to pharmaceuticals industry.
作者
杨世龙
马小芳
YANG Shi-long;MA Xiao-fang(Advanced Analysis and Testing Center,Nanjing Forestry University,Nanjing 210037,China)
出处
《四川林业科技》
2018年第6期25-30,共6页
Journal of Sichuan Forestry Science and Technology
基金
南京林业大学青年科技创新基金(CX2017004)
关键词
银杏内酯
银杏叶
提取
分离
检测
Ginkgolides
Ginkgo biloba leaves
Extraction
Separation
Detection
