摘要
目的:探讨胃癌根治术前动脉介入化疗对血清肿瘤标志物及病灶内细胞生长的影响。方法:选取在本院接受胃癌根治术治疗的原发性胃癌患者90例作为研究对象,根据术前是否接受动脉介入化疗将其分为对照组(术前未接受动脉介入化疗)48例、动脉介入化疗组(术前接受动脉介入化疗)42例。对比血清肿瘤标志物、胃癌组织中增殖及凋亡基因表达量的差异。结果:手术开始前,动脉介入化疗组血清中CA199、CA153、CA724、AFP的含量显著低于入组即刻,对照组血清中CA199、CA153、CA724、AFP的含量与入组即刻无显著差异(P>0.05)。手术后,动脉介入化疗组胃癌组织中增殖基因CUL4A、NTSR1mRNA的表达量低于对照组,DADS、FAM96B mRNA的表达量高于对照组;凋亡基因Livin、Bcl-2mRNA的表达量低于对照组,p53、p21、Bax mRNA的表达量高于对照组,差异均有统计学意义(P<0.05)。结论:术前动脉介入化疗联合胃癌根治术,可更为有效的抑制肿瘤恶性程度、延缓癌细胞生长。
Objective: To investigate the effect of arterial interventional chemotherapy before radical operation for gastric cancer on serum tumor markers and cell growth in the lesion. Methods: 90 patients with primary gastric cancer who underwent radical operation for gastric cancer in our hospital between February 2016 and October 2017 were chosen as the research subjects and divided into the control group ( n=48)(did not receive preoperative arterial interventional chemotherapy) and the arterial interventional chemotherapy group ( n=42)(received preoperative arterial interventional chemotherapy). The differences in tumor markers in serum as well as proliferation and apoptosis gene expression in gastric cancer tissues were compared. Results: Before surgery started, serum CA199, CA153, CA724 and AFP levels of arterial interventional chemotherapy group were significantly lower than those immediately after admission whereas serum CA199, CA153, CA724 and AFP levels of control group were not significantly different from those immediately after admission. After surgery, proliferation genes CUL4A and NTSR1 mRNA expression in gastric cancer tissues of arterial interventional chemotherapy group were lower than those of control group whereas DADS and FAM96B mRNA expression were higher than those of control group; apoptosis genes Livin and Bcl-2 mRNA expression were lower than those of control group whereas p53, p21 and Bax mRNA expression were higher than those of control group. Conclusion: Preoperative arterial interventional chemotherapy combined with radical operation for gastric cancer can more effectively inhibit the malignant degree of tumor and delay the growth of cancer cells.
作者
王明利
张少瑜
WANG Ming-li;ZHANG Shao-yu(Department of Intervention, Baoji Hospital of Traditional Chinese Medicine in Shaanxi Province, Baoji, Shaanxi Province, 721001;Department of Gastroenterology, Baoji Hospital of Traditional Chinese Medicine in Shaanxi Province, Baoji, Shaanxi Province, 721001)
出处
《海南医学院学报》
CAS
2018年第24期2174-2178,共5页
Journal of Hainan Medical University
基金
陕西省自然科学基础研究计划项目(2018JQ8061)~~
关键词
胃癌根治术
动脉介入化疗
肿瘤标志物
增殖基因
凋亡基因
Radical operation for gastric cancer
Arterial interventional chemotherapy
Tumor marker
Proliferation gene
Apoptosis gene
