摘要
目前乳腺癌是女性最常发病的恶性肿瘤之一,其中三阴性乳腺癌(TNBC)是恶性程度较高的亚型。TNBC因雌激素受体、孕激素受体、人类表皮生长因子受体2表达均为阴性,缺乏内分泌治疗及靶向治疗的常规手段,故其治疗更是成为当今医学领域的热点、难点。乳腺癌易感基因1(BRCA-1)是最早发现也是最主要的乳腺癌抑癌基因,近年来研究发现BRCA-1突变与TNBC的发生、发展密切相关。此外,微RNA在转录后水平对基因表达进行负性调控,发现在癌症中充当致癌基因和肿瘤抑制基因,并在TNBC中表达异常,通过多种分子机制促进TNBC细胞的增殖、侵袭及转移。
At present,breast cancer is one of the most common malignant tumors in women today.Three-negative breast cancer(TNBC)is a subtype with a higher degree of malignancy.TNBC is negative of estrogen receptor,progesterone receptor and human epithelial growth factor receptor-2expression,and lacks conventional methods of endocrine therapy and targeted therapy.Therefore,its treatment has become a hot and difficult issue in the medical field.Breast cancer susceptibility gene1(BRCA-1)is the earliest discovered and first major breast cancer suppressor gene.In recent years,it′s found that BRCA-1mutation is closely related to the occurrence and development of TNBC.In addition,microRNA negatively regulate gene expression on post-transcriptional level,acting as both oncogenes and tumor suppressor genes in cancer,with abnormal expression in TNBC,promoting proliferation,invasion and metastasis of TNBC cells through various molecular mechanisms.
作者
韩玲
苏乌云
呼群
HAN Ling;SU Wuyun;HU Qun(Department of Oncology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《医学综述》
2018年第23期4658-4662,4667,共6页
Medical Recapitulate
基金
内蒙古自治区自然科学基金(2016MS0820)
关键词
三阴性乳腺癌
乳腺癌易感基因1
微RNA
Triple negative breast cancer
Breast cancer susceptibility gene-1
MicroRNA
