摘要
F1Fo ATP synthase,or named ATPase(EC 3.6.1.3)(referred as the same enzyme hereafter)catalyzes the phosphorylation of ADP to ATP by exploiting a the transmembrane proton motive force(Δp)produced by the oxidation of nutrient substrates in mitochondrial respiration in all organisms.However,under peculiar physiological conditions when mitochondrial respiration is impaired which lead to the electrochemical gradient across the inner membrane collapse,the F1Fo ATP synthase switches its catalytic activity from ATP synthesis to ATP hydrolysis for maintaining theΔp.
基金
Key Program of National Natural Science Foundation of China(U1432248),Ministry of Science and Technology National Key R&D project(2016YFC0904600),National Natural Science Foundation of China(11405230,10835011,11205219).
