摘要
目的:观察柴胡疏肝散加减对反流性食管炎的治疗作用及复发率情况。方法:收集90例诊断为反流性食管炎且中医证型为肝胃不和型的患者。将其随机分为治疗组与对照组,每组均45例,对照组给予奥美拉唑肠溶口服;在此基础上,治疗组给予柴胡疏肝散加减治疗,疗程为8周,随访4周。结果:比较综合疗效:治疗组有效率为84.4%,优于对照组的75.6%,治疗组疗效优于对照组(P<0.05)。症状积分比较:治疗组有效率为91.1%,优于对照组的82.2%,差异均有统计学意义(P<0.05)。内镜下食管黏膜疗效比较:治疗组总有效率为86.0%,对照组为81.4%;两组内镜下食管黏膜炎症改善情况差异无统计学意义(P>0.05)。治疗组复发率明显低于对照组(P<0.05)。结论:柴胡疏肝散加减联合奥美拉唑治疗反流性食管炎,疗效明显优于单独使用奥美拉唑,复发率亦降低,值得临床推广。
Objective:To observe the therapeutic effect and recurrence rate of Chaihu Shugan San(柴胡疏肝散)on reflux esophagitis.Methods:90 cases of reflux esophagitis of the Ganwei Buhe type(肝胃不和型)were randomly divided into the treatment group and control group,45 cases in each.The control group was treated with omeprazole enteric-coated tablets.The treatment group was treated with Chaihu Shugan San more.The course of treatment was 8 weeks and the time of follow-up visiting was 4 weeks.Results:The comprehensive efficiency in the treatment group was 84.4%,superior to 75.6%in the control group(P<0.05).The efficiency of symptom score in the treatment group was 91.1%,better than 82.2%in the control group,with a statistically significant difference(P<0.05).The efficiency of endoscopic esophageal mucosa in the treatment group was 86.0%and 81.4%in the control group.There was no significant difference in the improvement of endoscopic esophageal mucosa between two groups(P>0.05).The recurrence rate in the treatment group was less than that in the control group,without statistical significance(P<0.05).Conclusion:Chaihu Shugan San plus omeprazole enteric-coated tablets on reflux esophagitis is more effective,and remarkably superior to omeprazole enteric-coated tablets purely,with less recurrence rate,and is worth promoting in clinic.
出处
《中医临床研究》
2018年第4期67-69,共3页
Clinical Journal Of Chinese Medicine
