摘要
激酶组学是近年研究较多的一类组学。激酶的磷酸化在调控细胞代谢和生理进程等方面起到重要作用,但原核生物激酶组学研究存在研究时间比真核生物晚、组氨酸激酶磷酸化无法检测等问题。通常通过对真核生物中激酶的研究,可以类比到原核生物中的激酶研究。对丝氨酸/苏氨酸激酶、酪氨酸激酶、组氨酸激酶在原核生物中的研究进展进行分析,并对激酶磷酸化的研究方法进行总结,阐明了激酶在原核生物中的重要调控作用。
Kinomics is a kind of omics that has enthusiastic attention in recent years.Phosphorylation of kinases plays an important role in regulating cell metabolism and physiology process.However,there are still some problems in the study of prokaryotic kinase,such as the shorter time study than eukaryotes and the difficulties in detection of the phosphorylation of histidine kinase.The study of kinases in prokaryotes can draw on the experience of that in eukaryotes.In this paper,we will review the progress of serine/threonine kinase,tyrosine kinase and histidine kinase in prokaryotes,summarize the methods of kinase phosphorylation and elucidate the important role of kinase in prokaryotes.
作者
薛闯
张萌
陈丽杰
Xue Chuang;ZHANG Meng;CHEN Li-jie(School of Life Sciences and Biotechnology, Dalian University of Technology, Dalian 116023, Dalian, China)
出处
《微生物学杂志》
CAS
CSCD
2017年第5期1-7,共7页
Journal of Microbiology
基金
国家自然科学基金项目(21576045
21376044)
中央高校基本科研业务费专项资金资助项目(DUT16YQ103)
关键词
原核生物
激酶
磷酸化
质谱
Prokaryotes
Kinase
Phosphorylation
Mass Spectrometric
