摘要
目的寻找一个主观性小而又实用的肾小球性血尿的诊断标准。方法首先采用普通光学显微镜确定特征变形红细胞(主要为环形、靶形和芽胞形3种),然后分析经过肾穿刺病理确诊的150例患者的特征变形红细胞的百分比,分成多个诊断值,分别计算敏感性和特异性,绘制受试者工作特征(ROC)曲线,并计算ROC曲线下面积(AUC)。结果肾小球性血尿患者特征变形红细胞百分比>30%,而非肾小球性血尿患者特征变形红细胞百分比<10%。以特征变形红细胞百分比>30%为标准,诊断为肾小球性血尿,其敏感性为84%、特异性为97%、AUC为0.976,同时显著缩小了混合型血尿的范围。结论以环形、靶形、芽孢形作为肾小球性血尿的特征变形红细胞,对诊断肾小球性血尿简单、易行,具有很好的实用价值。
Objective To seek a functional standard for the diagnosis of glomerular hematuria with little subjectivity.Methods Firstly,feature-deformed red blood cells(ring-,target-and spore-shaped red blood cells)were determined by light microscope,and its percentage in150diagnosed patients after renal biopsy was analyzed.Cut-off values were classified.The sensitivity and specificity were calculated,and receiver operating characteristic(ROC)curve was drawn.The area under ROC curve(AUC)was calculated.Results There were>30%featuredeformed red blood cells in patients with glomerular hematuria,while there were<10%feature-deformed red blood cells in patients without glomerular hematuria.Taking feature-deformed red blood cells>30%as standard for the diagnosis of glomerular hematuria,the sensitivity was84%,the specificity was97%,and the AUC was0.976.Meanwhile,the opportunity of processing mixed hematuria decreased.Conclusions Ring-,target-and sporeshaped red blood cells are practical for the diagnosis of glomerular hematuria.
作者
刘金祥
丁勇
曹翠云
潘妍
LIU Jinxiang;DING Yong;CAO Cuiyun;PAN Yan(Department of Nephrology,Shaoxing Hospital of China Medical University,Shaoxing 312030,Zhejiang,China)
出处
《检验医学》
CAS
2017年第7期582-585,共4页
Laboratory Medicine
关键词
肾小球性血尿
尿红细胞形态
特征变形
标准
Glomerular hematuria
Urinary red blood cell morphology
Feature deformation
Standard
