摘要
目的探讨脂联素水平对急性心肌梗死(AMI)患者急诊经皮冠状动脉介入治疗(PCI)术后心脏功能及临床预后的影响。方法连续入选2012年5月~2015年5月于河南大学淮河医院心内科收治行急诊PCI治疗的AMI患者110例,根据脂联素水平分为两组,其中A组76例(血清脂联素<8.5 mg/L);B组34例(血清脂联素≥8.5 mg/L)。比较两组患者实验室相关指标、超声心动图指标、冠状动脉造影检查指标、主要心血管事件(MACE)发生率及死亡率等。结果两组患者肌酐、尿素氮、超敏C反应蛋白、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A及载脂蛋白B水平比较差异无统计学意义(P>0.05);B组患者空腹血糖水平显著低于A组,差异有统计学意义(P<0.05)。两组患者左房内径和左室舒张末内径水平比较差异无统计学意义(P>0.05);B组患者左室射血分数水平显著高于A组,差异有统计学意义(P<0.05)。两组患者病变动脉支数、梗阻血管位置及冠状动脉TIMI分级比较差异无统计学意义(P>0.05);B组患者校正TIMI水平显著低于A组,差异有统计学意义(P<0.05)。两组患者住院和随访6个月死亡率比较差异无统计学意义(P>0.05);B组患者住院和随访6个月MACE发生率均显著低于A组,差异有统计学意义(P<0.05)。结论高脂联素水平可有效降低AMI患者急诊PCI术后MACE发生风险,改善心脏功能。
Objective To investigate the effects of adiponectin levels on cardiac function and clinical outcome of patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention (PCI). Methods 110 patients with AMI after emergency PCI were chosen from May 2012 to May 2015 in Huaihe hospital and divided into two groups: group A (76 patients with serum adiponectin <8.5 mg/L) and group B (34 patientswith serum adiponectin ≥8.5 mg/L). Laboratory-related indicators, echocardiographic parameters, coronary angiography, MACE incidence and mortality were compared between the two groups. Results There were no significant differences in the levels of Creatinine (Cr), Urea nitrogen (BUN), high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C),apolipoprotein A (Apo-A) and apolipoprotein B (Apo-B) in the two groups (P>0.05). The fasting blood glucose level in group B was significantly lower than that in group A (P<0.05). There was no significant difference in left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDd) levels between the two groups (P>0.05).The level of left ventricular ejection fraction (LVEF) in group B was significantly higher than that in group A (P<0.05). There was no significant difference in the number of arterial branches, obstruction vascular position and Thrombolysis In Myocardial Infarction (TIMI) grade of coronary artery between the two groups (P>0.05). The level of corrected TIMI frame count (CTFC) in group B was significantly lower than that in group A (P<0.05). There was no significant difference in mortality between the two groups (P>0.05). The incidence of MACE in group B was significantly lower than that in group A (P<0.05). Conclusion Higher adiponectin level on patients with AMI after emergency PCI can efficiently reduce the MACE occurrence risk and improve the cardiac function.
作者
李运伟
李彦明
洪岩
万琪琳
何瑞利
LI Yun-wei;LI Yan-ming;HONG Yan;WAN Qi-lin;HE Rui-li(Department of cardiology,Henan University Huaihe Hospital, Kaifeng 475000, China)
出处
《中国循证心血管医学杂志》
2017年第3期331-334,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
