摘要
目的:探讨他克莫司联合糖皮质激素治疗难治性肾病综合征的临床疗效。方法:收治难治性肾病综合征患者60例,随机分为观察组和对照组各30例,观察组采用他克莫司联合糖皮质激素治疗,对照组采用泼尼松联合环磷酰胺治疗,比较两组的治疗效果。结果:观察组总有效率96.7%,明显高于对照组的70.0%(P<0.05)。对照组的不良反应发生率高于观察组(P<0.05)。结论:他克莫司联合糖皮质激素治疗难治性肾病综合征的临床疗效显著,不良反应少。
Objective:To explore the clinical effect of tacrolimus combined with glucocorticoid in the treatment of refractorynephrotic syndrome.Methods:60 patients with refractory nephrotic syndrome were selected.They were randomly divided into theobservation group and the control group with 30 cases in each group.The observation group were treated with tacrolimus combinedwith glucocorticoid.The control group were treated with prednisone combined with cyclophosphamide.We compared thetherapeutic effect of the two groups.Results:In the observation group,the total effective rate of 96.7% was significantly higher than70% in the control group(P<0.05).In the control group,the incidence of adverse reactions was higher than that of the observationgroup(P<0.05).Conclusion:The clinical effect of tacrolimus combined with glucocorticoid in the treatment of refractory nephroticsyndrome was significant with few adverse reactions.
作者
龚俞函
Gong Yuhan(The People's Hospital of Pu'er City,Yunnan Province 665000)
出处
《中国社区医师》
2016年第6期61-61,63,共2页
Chinese Community Doctors
关键词
他克莫司
糖皮质激素
难治性肾病
Tacrolimus
Glucocorticoid
Refractory nephrotic syndrome
