摘要
目的:探讨糖尿病(DM)大鼠钙调节激素的变化。方法:测定实验性糖尿病大鼠及自由择食大鼠空腹血糖、胰岛素(Ins)、骨密度、骨钙素、降钙素、甲状旁腺激素(PTH)和维生素D3。结果:糖尿病大鼠与正常对照组相比,骨密度明显降低(P<0.01),骨钙素(BGP)水平有升高趋势,但无显著性差异(P>0.05),降钙素水平、维生素D3显著降低(P均<0.01),PTH显著升高(P<0.01)。结论:糖尿病状态下存在骨量减少、钙调节激素异常,主要表现为骨密度明显降低,甲状旁腺激素升高,维生素D3及降钙素水平降低。糖尿病骨质疏松可能与钙调节激素功能紊乱密切相关。
Objective:To explore the changes of regulating hormones for calcium in experi-mental diabetic rats.Method:The blood levels of fasting blood-glucose,insulin,bone mineral density(BMD),bone gla protein(BGP),calcitonin(CT),parathyroid hormone(PTH)and vitamin D3of experi-mental diabetic rats and free-feeding rats were measured.Results:The levels of BMD,CT and vita-min D3were significantly decreased(P<0.01),but the level of PTH were significantly increased(P<0.01)for the experimental diabetic rats compared with normal rats.The level of BGP showed rising tendency but had not significantly difference(P>0.05)for the diabetic rats.Conclusion:These results infer that experimental diabetic rats show osteopenia and abnormal calcium regulating hormones and diabetic osteoporosis might be closely related to dysfunction of regulating hormones for calcium.
出处
《海南医学院学报》
CAS
2002年第3期134-135,138,共3页
Journal of Hainan Medical University
关键词
糖尿病
大鼠
钙调节激素
骨质疏松
Diabetes mellitus
rats
parathyroid hormone
osteocalcin
calcitonin
