摘要
目的 观察短期应用静脉推注前列地尔 (prostaglandin E1)对不同时期糖尿病肾病患者肾功能及尿蛋白的影响。 方法 糖尿病肾病患者 81例 ,年龄 4 0～ 81岁 ;男 4 5例 ,女 36例。分为治疗组 4 5例和对照组 36例。两组患者均根据尿蛋白和肾功能的不同再分别分为早期肾病组、临床期肾功能正常组和临床期肾功能不全组 3个亚组。治疗组静脉推注前列地尔 (商品名 :凯时 ) 10μg,每日一次 ,连续 14 d。对照组不给上述治疗。控制血压、血脂、血糖等其他治疗方法各组相同。 结果 和对照组比较 ,治疗组患者尿总蛋白和尿白蛋白明显降低 ,其中糖尿病肾病早期组尿总蛋白由治疗前的 (0 .34± 0 .0 6 ) g/2 4 h下降到(0 .2 1± 0 .0 7) g/2 4 h(P<0 .0 1) ,尿白蛋白由 (191± 76 ) mg/2 4 h下降到 (99± 5 3) mg/2 4 h(P<0 .0 1) ;在临床期肾功能正常组尿总蛋白由 (3.74± 1.99) g/2 4 h下降到 (2 .38± 1.4 7) g/2 4 h(P<0 .0 1) ,尿白蛋白由 (2 85 5± 1790 ) mg/2 4 h下降到 (16 34± 10 93) mg/2 4 h(P<0 .0 1) ;在临床期肾功能不全组尿总蛋白由治疗前的 (1.89± 0 .93) g/2 4 h下降到 (1.84± 1.0 8) g/2 4 h(P>0 .0 5 ) ,尿白蛋白由 (14 0 7± 835 ) mg/2 4 h下降到 (1116± 5 5 7) mg/2 4 h(P<0 .0 5 )。
Objective To test the effect of prostaglandin E1 on proteinuria in the patients with diabetic nephropathy. Methods 81 patients with diabetic nephropathy were conducted into two groups. According to the excretion of urinary albumin and renal function, we evaluated the change of proteinuria for 3 subgroups(early stage DN, clinical stage with normal and abnormal renal function). 45 patients were treated with intravenous infusion of 10 μg Lipo PGE1 per day for 14 days. Among them, 16 patients were with early diabetic nephropathy and 29 patients with clinical diabetic nephropathy. 36 patients in control group. Results In treating group, proteinuria and albuminuria were significantly reduced as compared with the control group. In early stage DN, there was decreased proteinuria (0.21±0.07) g/24 h vs control (0.34±0.06) g/24 h and decreased albuminuria (99±53) mg/24 h vs control (191±76) mg/24 h, P <0.01). In clinical stage DN with normal renal function, proteinuria decreased (2.38±1.47) vs control (3.74±1.99) g/24 h, ( P <0.01) and albuminuria decreased (1 634±1 093) vs control (2 855±1 790) mg/24 h, ( P <0.01). In clinical stage DN with abnormal renal function, both proteinuria and albuminuria decreased (1.84±1.08) vs control (1.89±0.93) g/24 h( P >0.05) and (1 116±557) vs control (1 407±835) mg/24 h( P < 0.05 ) separately. Conclusion The administration of prostaglandin E1 may decrease proteinuria during distinct stages of diabetic nephropathy and these results did not change in last 6 month.
出处
《中国糖尿病杂志》
CAS
CSCD
2002年第5期276-279,共4页
Chinese Journal of Diabetes
关键词
前列地尔
糖尿病肾病
尿蛋白
影响
肾功能
Prostaglandin E1
Proteinuria
Albuminuria
Diabetic nephropathy
