摘要
目的:研究托瑞米芬对人肺腺癌细胞系A549的抑制作用及其与化疗药物联用的协同效应,以期为肺癌的临床治疗提供新的方向。方法:用MTT法检测不同浓度组药物对A549细胞的抑制作用。结果:托瑞米芬能直接抑制人肺腺癌A549细胞的生长,低剂量的托瑞米芬与化疗药物联用后的A值低于单用化疗药物组,其中与VCR、ADM、DDP、VP-16联用后的效果较好。结论:托瑞米芬与部分化疗药物联合应用对A549细胞系具有显著的协同抗肿瘤效应。这可能为肺癌的临床治疗提供实验依据。
Purpose:To study the activity of toremifene and its synergistic effect with anti-tumor drugs on human lung adenocarcinoma cell line A549,which might be expected to provide a new mode of therapy for the clinical management of lung cancer.Methods:The cytotoxic effects of these agents on human lung cancer cell line A549 were measured by a tet- razolium-based volorimetric assay (MTT assay).Results:Toremifene can inhibit the growth of A549 cell directly.The A value of the low dose toremifene combined with anti-tumor drugs were lower than that of anti-tumor drugs alone.Toremifene combined with VCR,ADM,DDP and VP-16 showed better effects.Conclusions:Toremifene combined with chemotherapy drugs shows significant synergistic anti-tumor effect on A549 cell.This might provide experimental evidence for lung cancer therapy.
出处
《中国癌症杂志》
CAS
CSCD
2002年第5期441-443,共3页
China Oncology
