摘要
目的:探讨肝动脉埋泵灌注化疔对肝癌根治术后复发的预防作用。方法:287例肝癌行根治术后随机分4组,分别埋置肝动脉化疗泵组、门静脉化疗泵组、肝动脉门静脉双埋化疗泵组、对照组(未置泵组)。所有泵内化疗2年,并追踪观察其术后复发情况。结果:肝动脉埋泵化疗组患者其术后复发率明显低于门静脉埋泵化疗组和对照组(P<0.01),与肝动脉门静脉双埋泵化疗组相比,差异无显著性(P>0.05)。同时肝动脉埋泵化疗能明显提高肝癌根治术后的一、二、三年生存率。结论:肝动脉埋泵化疗能延长肝癌术后的生存期及降低术后复发率。经胃十二指肠动脉的肝动脉埋泵化疗是安全有效的。
Purpose:To explore the preventive effect of hepatic arterial infusion (DDS) against recurrence of hepato- cellular carcinoma (HCC) after radical resection.Methods:From Jan,1996 to May,1998,287 patients of HCC after radical resection were randomly divided into four groups:intra-hepatic arterial infusion(97),intra-portal vein(80),intra-hepatic artery and portal vein (60),control (50).All patients received chemotherapy for two years and observed for postoperative recurrence of HCC.Results:The postoperative recurrence rate of HCC with intra-hepatic arterial infusion was significantly lower than that of intra-portal vein (P<0.01) or control,and was not different than that of intra-hepatic artery and portal vein (P>0.05).The 1～、2～ and 3～year survival rate of intra-hepatic arterial infusion was significantly higher than any of the other groups.Conclusions:Intra-hepatic arterial infusion (DDS) through gastro-duodenal artery can effectively pro- long the postoperative survival and decrease the post-operative recurrence rate of HCC.The preventive method of DDS through gastro-duodenal artery was safer and effective.
出处
《中国癌症杂志》
CAS
CSCD
2002年第5期433-434,共2页
China Oncology
关键词
术后
肝癌
埋泵化疗
复发率
生存率
hepatocellular carcinoma
hepatic arterial infusion chemotherapy
recurrence
survival rate
