摘要
目的:研究奥沙利铂与氟尿嘧啶、亚叶酸钙联合应用治疗晚期大肠癌的疗效和毒副反应。方法:采用奥沙利铂130 mg/m^2,静滴2小时,第1天;亚叶酸钙200 mg/m^2,静滴2小时,第1～5天;氟尿嘧啶300 mg/m^2(≤500mg/d),静滴4小时,第1～5天(亚叶酸钙滴完后用);21或28天为1周期。结果:总有效率为29.7%,毒副反应以骨髓抑制、感觉性神经毒性为主,白细胞减少45.9%,Ⅲ级和Ⅳ级为8.1%,感觉性神经毒性81.1%,Ⅲ级和Ⅳ级为5.4%。结论:奥沙利铂与氟尿嘧啶、亚叶酸钙联合应用治疗晚期大肠癌疗效肯定,毒副反应能耐受。
Purpose:To study the response and toxicity of the regimen of oxaliplatin combined with fluorouracil and calcium folinate in the treatment of consisting of advanced colorectal cancer.Methods:Thirty-seven patients with advanced colorectal cancer received chemotherapy of regimen:oxaliplatin 130 mg/m^2 2 hours iv on day 1,calcium folinate 200 mg/ m^2 iv 2 hours on days 1 to 5,followed by fluorouracil 300 mg/m^2(≤500 mg/d) iv 4 h on days 1 to 5,three or four weeks as one cycle.Results:The total response rate was 29.7%,the main toxicity was bone marrow suppression and neuro-sensory toxicity,leukopenia was observed in 45.9% of the patients,but grade Ⅲ and Ⅳ in only 8.1%,neuro-sensory toxicity was observed in 81.9.%,but grade Ⅲ and Ⅳ in only 5.4%.Conclusions:This study shows that the regimen of oxaliplatin combined fluorouracil and calcium folinate is effective and tolerable in advanced colorectal cancer therapy.
出处
《中国癌症杂志》
CAS
CSCD
2002年第5期419-420,共2页
China Oncology
