摘要
目的:研究CD44v6在胃癌组织中的表达,评估其在胃癌预后中的地位。方法:采用免疫组织化学EnVision^(TM)法,检测42例远隔癌灶部位"正常"胃粘膜和188例手术切除的胃癌组织中CD44v6的表达,并分析其与临床、病理特征的关系及对预后的影响。结果:CD44v6在胃癌组织中的阳性率为67.6%,明显高于远隔癌灶部位"正常"胃粘膜的表达(9.5%)(P<0.01),并与淋巴结转移有关(P<0.05)。Kaplan-Meier生存分析结果表明CD44v6表达与总生存率和无瘤生存率均显著相关(p<0.01),多因素分析结果表明脉管侵犯、TNM分期和CD44v6表达是影响胃癌患者生存率的独立预后因素(P<0.05)。结论:CD44v6在胃癌组织中具有较高的表达,有可能成为判断胃癌预后的有用指标。
Purpose:To study the relationship between the expression of CD44v6 with the clinicopathological charac- teristics and the prognosis in primary gastric carcinoma patients.Methods:A total of 188 paraffin-embedded gastric carcino- mas and 42 non-carcinomatous gastric mucosae was stained with the monoclonal antibodies CD44v6 using the EnVision^(TM) method.Results:The expression level of CD44v6 were significantly higher in the tumors (67.6%) than in the non-carcino- matous gastric mucosae (9.5%) (P<0.01).The expression level of CD44v6 protein was related to lymph node metastasis (P<0.05).Kaplan-Meier analysis revealed that patients with CD44v6-negative cancers had prolongation of overall survival (OS) and disease-free survival (DFS) (P<0.01).By multivariate analysis,it demonstrated that vessel invasion,TNM stage and CD44v6 expression played important roles in OS or DFS (P<0.05).Conclusions:The results suggest that CD44v6 is frequently expressed in primary gastric carcinoma,and CD44v6 might be used as one of the markers of poor prognosis in patients with gastric carcinoma.
出处
《中国癌症杂志》
CAS
CSCD
2002年第5期391-394,共4页
China Oncology
