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肿瘤坏死因子基因多态性与非霍奇金淋巴瘤发病的相关关系 被引量：4

STUDY ON THE RELATIONSHIP BETWEEN TUMOR NECROSIS FACTOR GENETIC POLYMORPHISM AND THE PATHOGENESIS OF NON-HODGKIN′S LYMPHOMA
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摘要 目的 :探讨肿瘤坏死因子 α(TNFα)基因 - 30 8位和淋巴毒素 (L Tα)基因 +2 5 2位基因多态性与非霍奇金淋巴瘤 (NHL)发病的关系。方法 :用聚合酶链反应 (PCR)、限制性内切酶消化及电泳技术 ,对 96例 NHL 患者和 72名正常对照者的 TNFα和 L Tα基因的单碱基突变多态性进行检测。结果 :TNFα基因型和两个等位基因频率在对照组中的分布与 NHL 患者类似 (P>0 .0 5 ) ,而 NHL 患者的 L Tα(5 .5 )基因频率较对照组升高 (NHL 患者 5 7.81% ,正常人 4 6 .5 2 % ,P=0 .0 4 )。结论 :TNFα基因多态性与 NHL 的发病无关 ,L Tα(5 .5 )等位基因可能与中国汉族人 NHL 发病的易感性有关。 Objective:To investigate the relationship between 308 bp polymorphism in tumor necrosis factor α(TNFα) gene and +252 bp in lymphotoxin α(LTα)gene and the pathogenesis of non Hodgkin′s lymphoma(NHL).Methods:The single base change polymorphism in TNFα gene and LTα gene were analyzed among 96 chinese patients with NHL and 72 normal controls by using PCR restrictive fragment length polymorphism(RFLP).Results:No difference of genotype or gene frequencies of TNFα was noted in patients and normal controls( P >0.05),whereas LTα(5.5)gene frequencies increased (NHL patients 57.81 %,healthy people 46.52 %, P = 0.04).Conclusion:TNFα gene polymorphism has no effect on NHL, but LTα(5.5)allelic type may be related to the susceptibility of Chinese Han population to some extent.
作者 赵洪云 陈运贤 钟雪云 欧瑞明 管慧红 陆英
机构地区 中山大学第一附属医院 暨南大学医学院
出处 《白血病．淋巴瘤》 CAS 2002年第5期275-278,共4页 Journal of Leukemia & Lymphoma
关键词 肿瘤坏死因子 基因多态性 非霍奇金淋巴瘤 Non Hodgkin′s lymphoma Tumor necrosis factor Gene polymorphism
分类号 R733.1 [医药卫生—肿瘤]
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参考文献10

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同被引文献57

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白血病．淋巴瘤
2002年 第5期

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