摘要
目的 研究天普洛安对阻塞性黄疸病人围手术期的肝肾功能的保护作用。方法 以我科连续收治的需手术治疗的阻塞性黄疸病人 4 2例为研究对象 ,2 4例为试验组 ,18例为对照组 ,试验组立即给予天普洛安静脉点滴 ,疗程为 5d ,对照组仅予以常规治疗。结果 术后 15d 2 4h尿量 (mg/kg) ,试验组病人明显多于对照组 ,其中以术后第 3天最为明显 ,差别有显著性 (P =0 0 14 ) ;术后第 5天试验组血清肌酐水平为 6 3± 18μmol/L ,对照组为 79± 2 7μmol/L ,差别有统计学意义 (P =0 0 2 8) ;两组术后AST、γ GT及总胆红素无明显差异 ,但试验组的各检验值恢复速度更快。结论 天普洛安对阻塞性黄疸病人围手术期的肝肾功能有保护作用。
Objective To examine the effects of perioperative administration of ulinastatin on liver and renal function in patients suffering from obstructive jaundice. Methods Forty two patients admitted to our hospital for surgical intervention on obstructive jaundice were randomly divided into two groups: The experimental group, 24 patients who were administered ulinastatin postoperatively, and the control group with 18 patients. Results The experimental group has more 24-hour urine volume (mg/kg) from postoperative day 1 to 5, the difference is statistically significant in day 3 (P= 0.014); The postoperative serum creatine level on day 5 in experimental group is significantly lower than control group(63±18 μmol/L vs 79±27 μmol/L, P=0 028); The postoperative serum AST, γ GT and TBIL level had no difference between two groups, however, the experimental group had more rapidly recovery speed. Conclusion Perioperative administration of ulinastatin has beneficial effects on liver and renal function in patients suffering from obstructive jaundice.
出处
《中华肝胆外科杂志》
CAS
CSCD
2002年第10期614-616,共3页
Chinese Journal of Hepatobiliary Surgery
关键词
阻塞性黄疸
病人
围手术期
肝功能
肾功能
Perioperative stage
Liver function
Renal function
Ulinastatin
