摘要
188Re标记octreotide可用直接标记法或间接标记法。直接标记法包括预锡化法和分步还原法,分步还原法需先用还原剂还原octreotide,然后用SnCl2还原188ReO4-进行直接标记;预锡化法则直接以SnCl2还原octreotide和188ReO4-,打开octreotide分子内双硫键,使188Re直接标记octreotide。预锡化直接标记法简便快速,能够得到较高的放化纯度,无须进一步纯化,适合用于制备药盒。
Octreotide can b e labelled with 188 Re by using the direct labelling approach and the bifunctional chelate ap-proach.The direct labelling approach concludes pretinning procedure and two-st ep reduction method.By pretinning pro-cedure,both octreotide and perrhenate are reduced by SnCl 2 .Rhenium of a lower oxidation state is bound to octreotide directly.By tw o-step reduction method,octreotide and the perrhenate are reduced by different reduction agent respec-tively.The direct radiolabelling approaches allow ve ry high radiochemical purity,high specific activity formulation,low radiocollo id formation and good in vitro stability,without the need for post-radiolabel ling purification to eliminate the un-bound free radioisotope.A kit could be d eveloped which would merely require the mixing of perrhenate with the other reag ents in a single vial.
出处
《国外医学（放射医学核医学分册）》
2002年第5期220-222,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
