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MIBG及其衍生物的研究进展 被引量：5

The recent research progress of MIBG and its derivatives
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摘要 MIBG(间碘苄胍)是神经递质去甲肾上腺素的功能性类似物,其转运、潴留与释放机制均与去甲肾上腺素相似。放射性核素标记的MIBG及其衍生物既可用于嗜铬细胞瘤、神经母细胞瘤等神经嵴起源肿瘤的诊断与治疗,也可用于心肌交感神经显像,评估心肌交感神经元的完整性与功能。 MIBG(metaiodobenzylguanidine)is a functional an alog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.
作者 罗全勇
机构地区 上海市第六人民医院
出处 《国外医学（放射医学核医学分册）》 2002年第5期216-219,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 放射性碘标记 诊断 治疗 MIBG 衍生物 研究进展 神经内分泌肿瘤 嗜铬细胞瘤 神经母细胞瘤 metaiodobenzylguanidine neu roendocrine tumor pheochromocytoma neuroblastoma myocardial sympathetic
分类号 R817 [医药卫生—影像医学与核医学]
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参考文献16

  • 1Vaidyanathan G, Zhao XG, Larsen RH, et al. 3-[~(211)At]-astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells [J]. Br J Cancer, 1997, 76(2): 226-233.
  • 2Cunningham SH, Maris RJ, Wheldon TE, et al. Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissio [J]. Br J Cancer, 1998, 77(12): 2016-2018.
  • 3Zhuang ZP, Kung MP, Mu MU, et al. 99Tcm-labelled MIBG derivatives: Novel 99Tcm complexes as myocardial imaging agents for sympathetic neurons[J]. Bioconjugate Chem, 1999,10(2): 159-168.
  • 4Stevens MJ, Raffel DM, Allman KC, et al. Regression and progression of cardiac sympathetic dysinnervation complicating diabetes: an assessment by C-11 hydroxyephedrine and positron emission tomography[J]. Metabolism, 1999, 48(1): 92-101.
  • 5Merlet P, Pouillart F, Dubois-Rande JD, et al. Sympathetic nerve alterations assessed with ~(123)I-MIBG in the failing human heart[J]. J Nucl Med, 1999, 40: 224-231.
  • 6Merlet P, Benvenuti C, Moyse D, et al. Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy [J]. J Nucl Med, 1999, 40: 917-923.
  • 7Maunoury C, Agostini D, Acar P, et al. Impairment of cardiac neuronal function in children dilated cardiomyopathy: an ~(123)I-MIBG scintigraphic Study[J]. J Ncul Med, 2000, 41:400-404.
  • 8Bengel FM, Barthel P, Matsunari I, et al. Kinetics of ~(123)I-MIBG after acute myocardial infarction and reperfusion therapy[J]. J Nucl Med, 1999, 40: 904-910.
  • 9Sakata K, Shirotani M, Yoshida H, et al. Cardiac sympathetic nervous system in early essential hypertension assessed by ~(123)I-MIBG[J]. J Nucl Med, 1999, 40:6-11.
  • 10Estorch M, Camprecios M, Flotats A, et al. Sympathetic reinnervation of cardiac allografts evaluated by ~(123)I-MIBG imaging[J]. J Nucl Med, 1999, 40:911-916.

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国外医学（放射医学核医学分册）
2002年 第5期

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