摘要
比较三钾二橼络合铋(TDB)与雷尼替丁对152例十二指肠溃疡(DU)的临床疗效。结果:TDB6周DU愈合率(78.5％)与雷尼替丁相近(65.2％)(X^2=2.89,P>0.05),但1年复发率(57.8％)低于后者(81.6％)(X=5.43,P<0.05)。TDB在清除幽门螺旋菌(HP)、减轻胃炎及十二指肠球炎、恢复十二指肠粘膜超微结构等均优于雷尼替丁。
One hundred and fifty-two patients with endoscopically diagnosed duodenal ulcer (DU) were randomised to receive either tripotassium dicitrate bismuthate (TDB) or randomised for 6 weeks, 76 cases in each group. The syntheses of PGE2, 6-keto-PGF1α and TXB2 of duodenal mucosa had been measured before and after therapy in 30 cases (TDB 16, ranitidine 14). Also the changes of the ultrastructure of duodenal bulb mucosa near the ulcers were detected by scanning electron microscope and transmission electron microscopy for the other 5 randomised patients of each group.
Results: the healing rates were 78.5% of TDB and 65.2% of ranitidine (X2=2.89, P>0.05). The 12 months' relapse of TDB was 57.8%, much lower than 81.6% of ranitidine (x2 = 5.432 P<0.05). TDB was more effective on the clearance of Helicobacter pylori (HP) and on the improvement of chronic active gastritis and duodenitis than rantidine. The ultrastructure of epithelial cell of duodenal mucosa restored to integrity after the clearance of HP treated with TDB, but no much changes were observed in those treated with ranitidine, neither HP nor the ultrastructure of epithelial cell. The syntheses of PGE2, 6-keto-PGF1α aed TXB2 of duodenal mucosa were not significant changing in TDB group. But 6-Keto-PGF1α was increased significantly in ranitidine group (T = 12, P<0.05).
It isc oncluded that TDB is effective as rantidine on the healing of DU. The clearance of HP accompanied with the recovery of ultrastructure of duodenal mucosa epithelial cell may be the mechanism of low relapse rate of TDB.
出处
《中山医科大学学报》
CSCD
1991年第4期295-298,F003,共5页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
TDB
十二指肠溃疡
雷尼替丁
Tripotassium dicitrate bismuthate Ranitidine Duodenal ulcer Helicobacter pylori Endoscopy Electron microscopy
