摘要
本文报道1例22岁女性伴原发闭经,男性化的肾上腺皮质腺瘤。血睾酮和尿17-KS升高,中剂量地塞米松抑制试验无反应。CT扫描得以定位诊断。显微镜检查为典型的肾上腺皮质腺瘤,未见Leydig细胞的组织学特征。肿瘤组织提取液经色—质联检证实为分子量284的去氢雄烯二酮。据悉,对此肿瘤组织的激素进行检测,本文属首次报道。结合文献复习,作者提出:凡疑似分泌雄激素瘤的患者,应作CT检查。激素的兴奋或抑制试验并不可靠。对肿瘤组织与血中雄激素水平的差异也进行了分析讨论。
A 22-year-old female with primary amenorrhea and virilization was found to have dehydroandrostenedione secreting adrenocortical adenoma, which was identified by GC-5970B series mass selective detecter. To our knowledge this may be the first published case involving measurement of androgen contents in the adrenal adenoma, The serum testosterone and urinary 17 ketosteroid levels were high. There was no response to dexamethasone suppression test. The tumor was localized at left adrenal by GT scan. Microscopic examination showed typical features of adrenocortical adenoma with no evidence of Leydig cells. Postoperatively, hirsutism regressed with regular monthly menstruation. Tracing the source of unreliable or false results, these tumors are usually rather large. Therefore, CT scanning of the adrenal glands is recommended in all patients with suspected androgen secreting tumor.
出处
《军医进修学院学报》
CAS
1991年第4期286-289,共4页
Academic Journal of Pla Postgraduate Medical School
