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MEF2与肌肉发生 被引量：7

MEF2 and Myogenesis
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摘要 MEF2属于MADS（MCM1,agamous,deficiens,serum response factor）框转录因子家族,在肌肉发生过程中起着重要的调节作用。本文综述了肌肉发生过程中MEF2,基因的表达调控、MEF2蛋白活性调节及其激活靶基因表达等,着重阐述了MEF2在钙调素一钙调磷酸酶与TGF-β-Smad通路中的作用,并分析了MEF2成为肌肉发生中承接信号分子与结构蛋白之间桥梁的原因。 Recent genetic and biochemical studies have demonstrated that skeletal muscle growth and differentiation in vertebrates are controlled by a core regulatory network which consists of two families of transcriptional factors,the MyoD group basic helix-loop -helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regulators. During development, MEF2 interacts genetically and physically with different members of this myogenic network and together they cooperate to positively or negatively regulate transcription of downstream muscle-specific differentiation genes. This paper reviews current understanding of molecular mechanism of these interactions and essential roles that MEF2 plays in skeletal muscle growth and differentiation during development.
作者 程震龙 朱大海 张志谦
机构地区 哈尔滨工业大学分子与细胞发育生物学实验室 北京大学临床肿瘤学院暨北京市肿瘤防治研究所细胞生物室
出处 《遗传》 CAS CSCD 北大核心 2002年第5期581-585,共5页 Hereditas（Beijing)
基金 国家杰出青年科学基金(No.300250) 国家高技术研究发展计划课题研究(2001AA222031)资助项目
关键词 MEF2 肌肉发生 信号传导 胚胎发育 MEF2 myogenesis signal transduction
分类号 Q753 [生物学—分子生物学]
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参考文献26

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同被引文献104

  • 1张文炜,徐列明.转录因子MEF2对多种信号通路的调节及其生物学作用[J].中国生物化学与分子生物学报,2004,20(4):423-427. 被引量：20
  • 2孙亮,朱小泉,王沥,金锋,杨泽.核辅激活因子PGC-1表达的分子调控机制[J].中国生物化学与分子生物学报,2005,21(4):431-439. 被引量：13
  • 3Gao C, Cheng X, Lava M, et al. Signal-dependent Regulation of Transcription by Histone Deacetylase 7 (HDAC7) Involves Recruitment to PML Nuclear Bodies. Mol. Biol. Cell 10.1091/mbc. E07-11-1203.
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  • 6Kim MS, Fielitz J, McAnally J, et al. Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance. Mol Cell Biol, 2008, 28(11):3600-3609.
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  • 10PADMAVATHY S N, DAVID C L, ROBERT Q T, et al. Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis [J]. Molecular and Cellular Biology, 1995,15(5) : 2707- 2718.

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