摘要
有效地控制人口增长,使用避孕药是其中重要措施之一.复方甲基炔诺酮乙片为一长效口服避孕药(以下简称长效复方18甲),避孕效果可靠,但不良反应甚多.在不影响其疗效的前提下,为减轻不良反应,使服药者乐于服用,作者采用家兔交配排卵法,观察长效复方18甲减量后的抗排卵作用.本实验将长效复方18甲人用临床剂量折算成家兔等效剂量,分为3个不同减量组、1个全量组和1个空白对照组,其中观察到3/4剂量组获得良好抗排卵效果,抗排卵率为80%,与全量组近似.
In order to alleviate the harmful effect of the long-acting oral contraceptive drug-Tab. Methylnorethindroni Ⅱ CO. (Containing Methylnorethindrone 12mg, quinestrol 3mg), its clinical dosage for men was converted into the equivalent dosage for rabbits according to certain formula, then the anti-ovulation effects of 3/4, 1/2 and 1/4 of this dosage were observed by the mateinducing ovulation method on rabbits. It was foubd that the 3/4 dosage group maintained a very good potency, its anti-ovulation rate was 80%.
出处
《泸州医学院学报》
1991年第3期175-177,共3页
Journal of Luzhou Medical College
关键词
避孕药
快诺酮
排卵
药理
Norethindrone
Contraception
Anovulation
Rabbits
