摘要
阵发性睡眠性血红蛋白尿症(PNH)为干细胞的一种异常克隆增生所致成的继发性血管内溶血疾患。通常无特效疗法。基于PNH 的骨髓增生特点,我们设计了COAT 治疗方案。T 系中药,COA 系常用化疗西药。COAT 方案治疗5例男性患者。治疗后血红蛋白不同程度恢复,骨髓象恢复正常,Ham 试验治后转成阴性或极弱阳性。按1987年上海全国溶血会议疗效标准,1例近期治愈,2例近期明显进步,2例近期进步。在继续观察中。
PNH is a secordary hemolysis inblood vessel,caused by hyperplasiaof abnormal clone of stem cells,andthere is usually no spical therapy,COAT treating scheme T system herbsand chemotherapy medicine were designed according tothe characferristiesof hyperplasia5cases were treated bythe COAT ssheme,and a some degreeof increase of haemoglokin was seenafter the treatment,Bone marrow pi-cture returned to normal,Ham testbecame negtive or poor positive,Onecase recovered,two cases with signif-icant progress,two coses withprogre-ss.according the standard of 1987Shanghai acdamic conference in hem-olysis.
