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甲基汞神经毒性检测和评价效应指标——即刻早期基因研究 被引量：5

Effective Index of Detection and Assessment on the Neurotoxicology of Methyl Mercury——Study on Immediate Early Genes
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摘要 论述了甲基汞神经毒性研究现状,通过分析即刻早期基因(IEG)在甲基汞神经毒性机制中的作用,得出即刻早期基因 能作为甲基汞神经毒性检测和评价的效应指标。同时也简要介绍即刻早期基因的研究方法,并指出利用基因芯片技术能够初步筛 选出甲基汞对大鼠脑基因表达影响的相关基因。 Review on the study progress of neurotoxicity of methyl mercury was presented, and the role of immediate early genes (IEG) in neurotoxic mechanism of methyl mercury was analyzed. The result showed that IEG could be used as an effective index of detecting and assessing neurotoxicology of methyl mercury. The study methods of expression of IEG were introduced, and the rat genes could be screened by the biochip.
作者 程金平 王文华 贾金平
机构地区 上海交通大学环境科学与工程学院
出处 《上海环境科学》 CAS CSSCI CSCD 北大核心 2002年第9期560-563,576,共5页 Shanghai Environmental Sciences
基金 国家自然科学基金项目 编号20177013 上海交通大学985工程项目 编号113516001。
关键词 毒性检测 评价效应指标 甲基汞 神经毒性 即刻早期基因 基因芯片 IEG 环境毒理 Methyl mercury Neurotoxicity Immedediate early genes Biochip
分类号 R994.6 [医药卫生—毒理学] X826 [环境科学与工程—环境工程]
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参考文献11

二级参考文献44

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共引文献55

同被引文献34

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引证文献5

二级引证文献20

上海环境科学
2002年 第9期

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