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化学致癌物质BBN的制备及其诱发大鼠膀胱肿瘤的作用 被引量:1

PREPARATION OF CHEMICAL CARCINOGEN BBN AND ITS INDLICTION OF BLADDER TUMOR IN RATS
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摘要 我们制备N—丁基—N—(4—羟基丁基)—亚硝胺(BBN),并用于诱发大鼠膀胱肿瘤,获得成功。 N—Butyl—N—(4—hydroxy—butyl)—nitrosamine(BBN) was prepared in Our laboratory, and we have Succeeded Success—fully to indvce bladder tumor in rats with this nitrosoamine.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 1991年第1期34-35,共2页 Cancer Research on Prevention and Treatment
关键词 BBN 膀胱肿瘤
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  • 1张东生,武文森.BBN诱发大鼠膀胱癌过程的电镜研究[J].南京医科大学学报(自然科学版),1994,14(3):447-449. 被引量:1
  • 2杨慎敏,温端改,侯建全,何军,岑建农,陈剑华.原位膀胱癌动物模型的建立及应用[J].癌症,2007,26(4):341-345. 被引量:10
  • 3Amit D, Hochberg A. Development of targeted therapy for bladder cancer mediated by a double promoter plasmid ex- pressing diphtheria toxin under the control of HI9 and IGF2- P4 regulatory sequences[J]. J Transl Med,2010,16(8) : 134.
  • 4Xiao Z, MeCaIlum TJ, Brown KM, et al. Characterization of a novel transplantable orthotopie rat bladder transitional eell tumour model[J]. Br J Ganeer,1999,81(4):638-646.
  • 5Irving CC, Cox R, Murphy WM. Influence of dose of N- methyl-N-nitrosourea on the induction of urinary bladder cancer in rats[J]. Cancer Lett,1979,8(1) :3-7.
  • 6Cohen SM, Hasegawa R, Sakata T, et al. Effect of aspirin on urinary bladder carcinogenesis initiated with N-[4-(5-nitro-2- furyl)-2-thiazolyl] formamide in rats[J]. Cancer Res, 1989, 49(2) :372-377.
  • 7Bohle A, Jurczok A, Ardeh P, et al. Inhibition of bladder carcinoma cell adhesion by oligopeptide combinations in vitro and in vivo[J]. J Urol,2002,167(1) :357-363.
  • 8Asanuma H, Arai T, Seguchi K, et al. Successful diagnosis of orthotopic rat superficial bladder tumor model by ultrathin eystoscopy[J]. J Urol, 2003,169 (2) : 718-720.
  • 9Kunze E, Schulz H, Adamek M, et al. Long-term adminis- tration of galactoside-specific mistletoe leetin in an animal model: no protection against N-butyl-N-(4-hydroxybutyl)-ni- trosamine-induced urinary bladder carcinogenesis in rats and no induction of a relevant local cellular immune response[J]. J Cancer Res Clin Oncol,2000,126(3) :125-138.
  • 10Chen T, Na Y, Wanibuchi H, et al. Loss of heterozygosity in (LewisxF344) F1 rat urinary bladder tumors induced with N- butyl-N-(4-hydroxybutyl) nitrosamine followed by dimethyl- arsinic acid or sodium L-ascorbate[J]. Jpn J Cancer Res, 1999,90(8) :818-823.

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