摘要
1989年前列腺癌已超过肺癌成为美国男子中发病率最高的恶性肿瘤。前列腺癌的治疗包括前列腺全切除术、放疗、内分泌治疗和化疗等,本文就近年来治疗的发展作一综述。 前列腺全切除术 前列腺全切除术于1905年由Young首先提出,一直作为局限性前列腺癌的主要治疗手段,七十年代后,面临放疗的竞争。前列腺全切除术有经耻骨后,和经会阴两个手术途径,全部切除前列腺腺体、包膜、精囊和输精管壶腹,将膀胱颈和膜部尿道吻合。这一手术的理想适应证是患者较健康、有超过十年以上生存期望。
This is a review on advance in the treatment of prostatic adenocarcinoma including radical prostatectomy. radiation therapy, hormonal therapy and chemotherapyetc. In patients with Iocalized disease. long-term disease--free survival has beenreported after radical prostatectomy. A modified nerve-sparing technique is used inan effort to av?id impotence after operation. Radiation therapy is an alternative treat-ment for localized prostate cancer. But if radiation therapy is a rational modalityfor locally advanced prostate cancer remains controversial. Hormonal treatment isadministered in metastatic cancer. New modalities such as LHRR agonists and anti-androgens are now available. In recent years, patients receiving combination therapysuch as LHRH agonists plus nonsteroida antiandrogens enjoy superior progression-free and median survial rates. The clinical benefits of chemotherapy aremodest. The efficacy of other treatment such as immunotherapy and cryotherapy isuncertain.
出处
《肿瘤》
CAS
CSCD
北大核心
1991年第2期57-59,共3页
Tumor
