摘要
Purpose To report a case of primary in traocular lym-phoma possessing bilaterally ident ical monoclonal rear-rangements of the immunoglobulin heavy chain(IgH)gene.Design Observational case rep ort.Methods A 78-year-old woman with bilateral vitritis,subretinal infil-trates in the right eye,and no involv ement of the central nervous system(CNS)was diagnosed histologically with diffuse large B-cell lymphoma by a tr ansvitreal subretinal biopsy of the right eye.One month later,vitrectomy was performed on the left eye due to incre ased vitreous opacity.DNA was extracted from a vitrectomy s pecimen from each eye,and the third complementarity-determining region of IgH gene was analyzed by polymerase c hain reaction and direct sequencing.Results Monoclo nal rearrangements of IgH gene with identical DNA sequence were detected in both eyes.Conclusions Bilaterally identical monoclonality was detected in a case of primary intr aocular lymphoma with no CNS involvement.
Purpose To report a case of primary in traocular lym-phoma possessing bilaterally ident ical monoclonal rear-rangements of the immunoglobulin heavy chain(IgH)gene.Design Observational case rep ort.Methods A 78-year-old woman with bilateral vitritis,subretinal infil-trates in the right eye,and no involv ement of the central nervous system(CNS)was diagnosed histologically with diffuse large B-cell lymphoma by a tr ansvitreal subretinal biopsy of the right eye.One month later,vitrectomy was performed on the left eye due to incre ased vitreous opacity.DNA was extracted from a vitrectomy s pecimen from each eye,and the third complementarity-determining region of IgH gene was analyzed by polymerase c hain reaction and direct sequencing.Results Monoclo nal rearrangements of IgH gene with identical DNA sequence were detected in both eyes.Conclusions Bilaterally identical monoclonality was detected in a case of primary intr aocular lymphoma with no CNS involvement.
出处
《世界核心医学期刊文摘（眼科学分册）》
2005年第1期21-21,共1页
Digest of the World Core Medical Journals:Ophthalmology
