摘要
采用天花粉、黄精、玄参、知母等常用治疗糖尿病的中药,针对胰岛素与外周组织胰岛素受体结合这一环节,观察是否影响其结合率,进行正常人体外的实验性研究。除知母显示降低胰岛素与人红细胞胰岛素受体的结合率外,余三味中药未见对结合率有明显影响。
Chinese herbal drugs,Trichosauthes kirlowii(TK),Polygonatum sibiricum(PS),Scrophularia ningpoensis(SN),Anemarrhea asphodeloides(AA)were selected for the study of their effects on the binding of insulin with human erythrocyte insulin receptor.The results inicated that TK,PS,SN did not increase nor decrease the insulin receptor binding rate,whereas AA provoked a marked inhibit- ing effect on the rate of binding(P<0.01).These findings cannot completely deny the beneficial effect of the compound prescription of these drugs in the treatment of diabetes mellitus because of the following reasons:(1)The experiments were done in vitro but not in vivo and the erythrocytes from normal men but not from diabetics.(2)The drugs were not put together during exaction as in the traditional manner,but was studied separately.(3)The fact that there is no effect on insulin receptor binding cannot rule out their beneficial effect on other aspects of insulin or insulin secretion even on the amelioration of tissue insulin resistance.
关键词
天花粉
胰岛素
黄精
胰岛素受体
insulin
erythrocyte insulin receptor
Trichosauthes kirilowii
Polygonatum sibiricum
Scrophularia ningpoensis
Anemarrhea asphodeloides
