摘要
应用放射配体结合测定法,测定22例更年期综合征患者白细胞雌激素受体(ER)的含量,并与12名正常育龄妇女比较。结果表明:更年期综合征患者白细胞 ER 的含量明显低于正常育龄妇女。提示更年期综合征的发病不仅与雌激素水平下降有关,而且也与细胞内 ER 下降有关。应用六味地黄丸治疗2个月后,除症状改善外,可使白细胞 ER 含量及血浆雌二醇(E_2)水平明显增高。这可能是此种中药发挥疗效的基础。
The numbers of estrogen receptor(ER)in human peripheral leucocytes in 22 women with climacteric syndrome were measured by radioligand method.The results were compared with those of 12 normal child-bearing-age women.It wat found that the contents of leucocytic ER in climacteric syndrome patients were significantly lower than normal child-bearing-age women.The authors used a Chinese prescription—Liuwei Dihuang Pills(LDP)to treat the patients for 2 months.The numbers of leucocytic ER were significantly increased after treatment.The data indicate that decrease of ER levels in cell may involve in the pathogenesis of climacteric syndrome.LDP not only increases plasma estradiol levels,but also increases the leucocytic ER levels.This may be the basis-of the therapeutic effect on the disease.
关键词
雌激素受体
更年期综合征
雌二醇
estrogen receptor
estradiol
climacteric syndrome
Liuwei Dihuang Pills
