摘要
本实验对比研究了中药巴戟天、鄂西巴戟天和川巴戟的某些补虚扶正和助阳的作用及其毒性,口服巴戟天和鄂西巴戟天水煎液能显著增加小白鼠体重、延长持续游泳时间、抑制幼年小鼠胸腺萎缩、升高其血中白细胞数,并能增加甲状腺功能低下(甲减)小鼠的耗氧量,使甲减小鼠脑中升高的 M 受体最大结合容量恢复正常。作用强度以巴戟天尤佳,川巴戟水煎剂效果不明显。大白鼠口服三种巴戟天水煎剂未见雄性激素样作用;经小鼠口服给药未见急性毒性;经大肠杆菌体外 SOS 比色分析亦未见有致诱变作用。
There are three kinds of plants,Morinda officinalis(1),Damnacanthus officinarum(2),and Schisandra propinqua(3)whose roots have been used since the ancient time.In this paper,some of their pharmacological actions that are related to tonifying and invigorating Yang(阳)were examined and compared.The body weight,the thymus weight,the amount of leukocyte in the blood, and the continuing swimming times of the young mice could be increased with the oral administra- tion of the water extractions of(1)and(2)(P<0.05～0.001).The Rt of M-receptor in the brains of the hypothyroidism mice were decreased after administration of the water extracts of(1)and(2) (P<0.05).(1)could also increased the amount of leukocyte in the blood of leukocytopenia mice caused by radiation of γ-ray(P<0.01).(3)has not shown the obvious effects(P>0.05).The results indicate that(1)and(2)have the ability of anti-fatigue,improving the immunological action of the young mice,and reducing the exitability of the para-sympathetic nervous system of the hypothyr- oidism mice through decreasing the Rt of M-receptor in their brains.All of them did not show acute toxicity,inducing mutation,and sexual hormone like actions.
关键词
巴戟天
药理
补益助阳
M受体
Morinda officinalis
Damnacanthus officinarum
Schisandra propinqua
M-receptor
immunoenhancement
