摘要
本实验采用 RIA 方法,检测复方丹参注射液对兔血管是活性肽——血管紧张素Ⅱ(AngiotensinⅡ,AⅡ)、心房利钠多肽(Atrial Natriuretic Polypeptide,ANP)的影响。发现用药后兔血浆 AⅡ、ANP 显著低于对照组(P<0.05):脑、心匀浆 AⅡ及 ANP 轻度降低,但无统计学意义(P>0.05)。提示复方丹参降压、扩张血管机制可能与血管活性肽变化有关。
Both angiotensin Ⅱ(AⅡ)and atrial natriuretic polypeptide(ANP)are related to the function of blood vessels,but differ in their actions.The authors observed the effect of Salvia miltiorrhiza Co. (SMC)on the activities of AⅡ and ANP in rabbits by radioimmunoassay.It was found that the concentration Of AⅡ and ANP in plasma were significantly lower(P<0.05),and slightly lower in brain and atrial(P>0.05)in SMC group than in control group.It indicated that the effect of SMC on blood vessels is related to changes of AⅡ and ANP,and that the difference of peptide changes in brain and plasma might be due to the blood-brain barrier.
关键词
复方丹参
血管紧张素II
Salvia miltiorrhiza Co.,angiotensin Ⅱ
atrial natriuretic polypeptide
