摘要
用中药血栓心脉宁胶囊采取随机对照法,治疗脑血栓158例,治愈显效率为62.1%,总有效率为96.3%;对照组用低分子右旋糖酐加维脑路通治疗117例,治愈显效率为38.5%,总有效率为86.3%。两组比较差别有显著性意义(P<0.01)。实验证明,该药具有改善脑、心缺血作用,增加脑血流量,降低血脂、血粘度、红细胞压积和血小板聚集率(P<0.01)。药理实验亦证实该药可明显抑制和延缓正常家兔实验性血栓形成,抑制血小板聚集,降低血脂和血粘度,抗缺氧,增加血流量。该药无毒副作用,是治疗脑血栓安全有效的药物。
Antithrombotic Xinmaining were composed with Moschus,Calculus Bovis,Borneol,Radix Ligusticum,Flos S ophorae Immaturus,Radix Salviae Miltiorrhizae,Leech,etc.This preparation was suitable for treating channels and collaterals type of cerebral thrombosis.The dosage was 2～ 4 capsules (0.5g/capsule) oral.administration twice per day,3～4 weeks as a therapeutic course.The authorsstudied 158 cases of these patients compared with 117 cases of control group with dextran and Vinorutone.The clinical result showed that the obvious effective rate in the therapeutic group was.62.1% and the total effective rate 96.3%;the values in the control group were 38.5% and 86.3% respectively (P<0.01).The laboratory results Showed that the blood viscosity,serum viscosity, hematocrit (vol %),RBC electrophoresis rate(μm/sec/v/cm)and platelet aggregation rate (%) before antithrombotic Xinmaining administration were 5.82±0.82,1.82±0.02,52.81±6.70,0.82±0.19 and 28.33±12.02 respectively;and those after the treatment were 4.72±0.65,1.70±0.02,48.76±0.40, 0.97±0.17 and 23.05±10.01((?)+ S),P<0.01.The toxicological study proved that the preparation was safe,no significant side-effect and good for cerebral thrombosis medication.
关键词
血栓心脉宁
脑血栓
血液流变性
cerebral thrombosis
antithrombotic Xinmaining
hemorheology
