药物对神经生长因子基因表达的调控及其作用机理
摘要
神经生长因子对中枢神经系统的保护作用已被广泛证实,但是由于不能透过血脑屏障因而在给药方法和疗效上有一定的局限性,研究发现一些激素、维生素和神经递质等能够不同程度地增加内源性神经生长因子表达,有助于克服上述局限。以β2-受体激动剂克仑特罗（clenbuterol）为重点介绍了这些药物对神经生长因子基因表达调节作用和机理。
出处
《国外医学（神经病学．神经外科学分册）》
2002年第4期379-381,共3页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
参考文献14
-
1Emmett CJ, McNeely PA, Johnson RM et al Evaluation of human astrocytoma and glioblastoma cell lines for nerve growth factor release. Neurochem Int. 1997,30(4-5): 465-474.
-
2Samina RS, Tomlinson DR. Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2) - adrenoceptor agonists. Brain Res Mol Brain Res, 2000, 85(1- 2) : 179- 188.
-
3Shadrina MI, Dolotov OV, Grivennikov IA, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Scmax, an adrenocorticotropic hormone analog. Neurosci Lett, 2001,308(2): 115- 118.
-
4Krzan M, Wu VW, Schwartz JP. Serotonin regulation of nerve growth factor synthesis in neonatal and adult astrocytes: comparison to the beta-adrenergic agonist isopreterenol. J Neurosci Res, 2001,64(3): 261-267.
-
5Granholm AC Oestrogen and nerve growth factor - neuroprotection and repair in Alzheimer' s disease. Expert Opin Investig Drugs, 2000, 9(4) : 685 - 694.
-
6Semkova I, Schilling M, Henrich - Noack P, et al. Clenbuterol protects mouse cerebral cortex and rat hippocampus from Ischemic damage and attenuates glutmate neurotoxicity in cultured hippocampal neurons by induction of NGF. Brain Res , 1996, 717(1 -2):44-54.
-
7Culmsee C, Semkova 1, Krieglstein J. NGF mediates the neuroprotective effect of the β2- adrenoceptor agonist clenbuterol in vitro and in vivo:evidence from an NGF- antisense study. Neurochem Int , 1999, 35(1):47-57.
-
8Zhu Y, Culmsee C, Semkova I. et al . Stimulation of β2- adrenoceptors inhibits apoptosis in rat brain after transit forebrain isehemia. J Cereb Blood Metab , 1998,18(9) : 1032 - 1039.
-
9Colangelo AM, Follesa P, Mocchetti I. Differential induction of nerv growth factor and basic fibroblast growth factor mR.NA in neonatal and aged rat brain. Mol Brain Res, 1998,53(1 - 2): 218-225.
-
10Semkova I, Krieglstein J . Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors. Brain Res Rev, 1999,30(2) : 176- 188.
-
1袁慧,张苏明.Alzheimer病多重转基因小鼠模型研究进展[J].中华老年医学杂志,2004,23(12):896-898. 被引量：1
-
2余鸿,程基焱,吴雨岭,王特为,韩艺,王琼.缺血性脑损伤大鼠下丘脑c-fos基因表达及药物调控[J].泸州医学院学报,2001,24(1):25-27. 被引量：1
-
3齐鹏,杨晓庆,杜志敏,徐志强,邬旺,贺亚杰,李万里.阿尔兹海默症动物模型的研究现状[J].新乡医学院学报,2013,30(10):838-841. 被引量：7
-
4章军建,王涛.混合性认知损害——一个临床新概念[J].中华医学杂志,2016,96(45):3634-3636. 被引量：4
-
5李阳阳,刘承伟.帕金森病中非运动症状发病机制的研究现状[J].华夏医学,2015,28(1):163-166. 被引量：1
-
6郭颂,饶明俐.Clenbuterol对海人藻酸所致大鼠海马组织培养损伤的保护作用研究[J].中风与神经疾病杂志,2000,17(3):130-132. 被引量：2
-
7彭孟圆,仓静,方芳.谷氨酸转运体-1相关核转录因子及其药物调控的研究进展[J].临床麻醉学杂志,2017,33(4):408-411. 被引量：2
-
8杜业亮,王纪佐,冯进波.局灶缺血诱导大鼠脑肝细胞生长因子表达的动态观察[J].脑与神经疾病杂志,2004,12(6):423-424. 被引量：6
-
9徐元,胡丽芳,刘春风.他汀类药物与帕金森病[J].中国临床神经科学,2015,23(5):563-569.
-
10马晓伟,刘娜,王彦永,王铭维,顾平.重复经颅磁刺激治疗帕金森病的机制研究进展[J].中华物理医学与康复杂志,2009,31(11):783-785. 被引量：4
