摘要
我们对21例烧伤面积大于30%以上患者,单独应用雷尼替丁预防上消化道出皿,资料显示该药对控制胃液分泌量、pH值及胃液游离酸、总酸度均取得满意的效果。临床均无明显的上消化道出血的征象。
This paper reports the use of Ranitidine in preventing upper gastrointestinal tract hemorr- hage following thermal injury. In 12 hours after intravenous injection of Ranitidine, gastric pH was elevated from 3.25 ± 0. 26 to 5.16 ± 0.47 (P<0.01) in tweaty-one burn patients, with mean TBSA 62.6% ± 17.2% (31%～87.5%), mean third degree BSA 41.4% ± 18.3% (0～68%). The volume of gastric secretion was decreased from 15.81 ± 4.4ml to 2.85 ± 0. 9ml. The free acid of gastric secretion was decreased from 25.74 ± 1.42mmol/L to 5.98 ± 3.68mmol/L (P<0.01). The total titratable acidity of gastric secretion was decreased from 44.76 ± 5.76mmol/L to 13.85 ± 2.02mmol/L (P<0.01). Three patients had occult blood in their gastric contents on admission, and it turned negative after Ranitidine therapy. However, during 1987～1988, the incidence of upper gastrointestinal tract hemorrhage of fifty-one patients with similar TBSA and third degree BSA burned was 21.6%. Changes in gastric secretion and lowered incidence of upper gastrointestinal hemorrhage after Ranitidine therapy suggest that Ranitidine may be effective in preventing upper gastrointestinal tract hemorrhage following thermal iujury.
