摘要
目的 评价短期应用雷贝拉唑和奥美拉唑对十二指肠溃疡 (DU)患者症状的治疗作用及其安全性。方法 多中心、随机、双盲、平行对照研究。将活动期DU患者随机分为雷贝拉唑 (1 0mg/d)治疗组和奥美拉唑 (2 0mg/d)对照组。 2组均服药 7d。记录治疗前和用药期间的腹痛、反酸、腹胀和嗳气症状的变化及有无不良反应出现。结果 治疗组和对照组分别完成了 1 0 8例和 1 0 3例患者的观察。治疗组的腹痛平均消失天数为 (3 1± 1 7)d ,与对照组 (3 2± 1 8)d相同。治疗组和对照组服药期间每天的腹痛消失率无明显差异。用药第 1天时治疗组的腹痛缓解率为 56 % ,明显高于对照组的 33 % (P <0 0 5) ,其余各天内 2组间无差异。治疗组患者第 7天的反酸消失率为 1 0 0 % ,明显高于对照组的 83 % (P <0 0 5)。 2组患者的每天腹胀和嗳气的消失率差异均无显著性。 2组均无不良反应发生。结论 雷贝拉唑及奥美拉唑均对DU患者的症状具有良好的治疗作用 ,而雷贝拉唑在服药第 1天对腹痛及第 7天对反酸的缓解作用更为明显。
Objective To evaluate the therapeutic effect on duodenal ulcer symptoms and safety of rabeprazol as comparied with omeprazole Methods This is a multicenter, randomized, double blind, controlled trial Patients with active duodenal ulcer were devided into group A treated with rabeprazole 10 mg/day and group B treated with omeprazole 20 mg/day The duration of treatment was 7 days in both groups All the symptoms including abdominal pain, acid regurgitation, belching and abdominal bloatness were evaluated before and during the treatment Results All patients enrolled in group A(108 cases) and group B(103 cases) went through the study Between the two groups, there were no differences in the mean time of partial and complete pain relief rates every day The partial pain relief rate on day one was higher in group A (56%) than that in group B (33%, P <0 05) On day seven , acid regurgitation relief rate was higher in group A than that in group B (100% and 83%, respectively, P <0 05) No significant difference in the rate of partial pain relief and acid regurgitation on the other days of the treatment The relief rate of abdominal bloatness and belching everyday in the two groups were similar No adverse events took place in both groups Conclusions Rabeprazole(10 mg/day) has excellent therapeuitc effect on the symptoms of duodenal ulcer patients The effects on the relief of pain and acid regurgitation are better than those of omeprazole Rabeprazole for short term using is safe
出处
《中华内科杂志》
CAS
CSCD
北大核心
2002年第9期589-591,共3页
Chinese Journal of Internal Medicine
