摘要
目的 :探讨从植物药中筛选新先导化合物以及创制具有我国自主知识产权新药的策略。方法 :简述从中药经、验方中筛选可能起主要治疗作用的单一植物以及由该植物有效成分中筛选先导化合物的意义和方法。结果 :在中医药临床实践过程中 ,针对某一类疾病的治疗 ,可发现某些特定药物的应用频率较高 ,从而由此推测出该药物含有对该型疾病起治疗作用的有效成分。结论 :从传统中医药用植物的有效成分中筛选先导化合物具有一定的确定性和方向性 ,采用从植物药中筛选先导化合物的策略可能加快我国开发、创制新药的速度。
OBJECTIVE:To discuss the strategy for screening new leading compounds and discover the novel drug candidates,which have the independent intelligent property right,from botanicals METHODS:Screening the new leading componds from the single plant which plays the main therapeutic role in classical prescriptions or proved recipes were reviewed RESULTS:The results showed that the frequency of use of certain kinds of plant was higher than that of the others in treatment of certain disease,it is hypothesized that the plant may contain the active ingredient for the therapy of certain kinds of disease CONCLUSION:Screening new leading compound from Chinese materia medica is a shortcut with less risk,which may promote the development of new drugs in China
出处
《中国药房》
CAS
CSCD
2002年第9期516-518,共3页
China Pharmacy
