摘要
目的 研究 Ig A肾病 (Ig A nephropathy,Ig AN )患者的临床特征和病理分级与预后的关系 ,为临床治疗及预后判断提供依据。方法 对 38例经病理诊断确诊为 Ig AN患者的临床特点及病理报告资料与预后进行比较分析。结果 Ig AN患者的临床特征以发作性肉眼血尿及无症状性尿异常最多见 (占 6 5 .8% )。 Ig AN合并急性肾功能衰竭 (acute renal failure,ARF)患者几乎没有长期的后遗症。不同病理分级患者的临床类型间的差异有显著性 (P <0 .0 1) ,不同病理分级患者的合并症的差异有显著性 (P <0 .0 1) ,提示病理分级愈高 ,肾损害愈严重 ,预后愈差。重度蛋白尿组的尿素氮 (Bu N)和血肌酐 (SCr)显著高于轻中度蛋白尿组 (P <0 .0 1)。结论 少数 Ig AN患者可合并 ARF,多为可逆性 ;长期大量蛋白尿预示肾功能的进行性损害。
Objective Study on the relationship between clinical feature, pathologic grade and prognosis of IgA nephropathy (IgA nephropathy,IgAN), in order to provide the clues for clinical treatment and prediction of prognosis. Methods The relationship between clinical situation, pathological degree and prognosis of 38 IgAN patients were analyzed. Results The clinical situation of macroscopic hematuria and asymptomatic abnormal composition of urine were dominant (65.7%) on IgAN patients and the longer sequelae almost did not happen on IgAN patients who merged acute renal failure (ARF). There was different significantly among clinical situations of different pathological degree ( P <0.01). There was also different significantly among clinical merged situations of different pathological degree ( P <0.01). And the higher pathological degree may predict more severe renal damage and poor prognosis. There were higher BuN and serum creatinine significantly in patients with heavy proteinuria than that in patients with minimal or moderate proteinuria. Conclusions Some IgAN patients can merged with ARF, and the clinical situation of ARF were reversible. The clinical situation of continuous and severe proteinuria could hasten the developing of renal failure on IgA nephropathy patients.
出处
《疾病控制杂志》
2002年第3期205-208,共4页
Chinese Journal of Disease Control and Prevention
