摘要
目的 探讨小儿乙型肝炎病毒感染合并急性黄疸型甲型肝炎的乙型肝炎病毒血清标志物的变化。方法 对甲乙型肝炎病毒重叠感染的小儿抽血检测肝功能、抗 HAVIgM和乙型肝炎病毒血清标志物HBVM ,(包括HBsAg、抗 HBs、HBeAg、抗 HBe、抗 HBc、抗 HBcIgM ) ,并与慢性HBV感染者进行对比分析。结果 重叠感染组HBsAg阴转率为 18.2 % ,明显高于对照组的 2 .2 %(P <0 .0 5 )。阴转组HBsAg滴度 (41.5± 2 .7)明显低于非阴转组 (188.1± 3.3) ,P <0 .0 1,两组HBeAg阳性率分别是 16 .7%和 6 5 .7% (P <0 .0 1)。结论 重叠感染组HBsAg阴转率明显高于对照组 ,并且部分非阴转病例可见到HBsAg滴度下降 ,说明肝炎病毒间存在着干扰现象 。
Objective To explore the changes of hepatitis B virus markers(HBVM) in infant patients with hepatitis B virus(HBV) complicated with acute icteric hepatitis A (HA).Methods Blood tests were made among infant patients with overlapping infection of HBV and HAV to detect their liver functions.Analyses of anti HAVIgM and HBVMs including HBsAg,anti HBs,HBeAg,anti HBe,anti HBQ and anti HBcIgM were made between the overlapping infection group and the chronic HBV group.Results The rate of negative transformation in the overlappling infection group was 18.2%,2.2% higher than that in the contrast group(P<0.05).The titer of negative transformation(41.5±2.7) in the overlapping infection group was obviously lower than that in the other group(188.1±3.3)(P<0.01).The positive rates of HBeAg in the two groups were 16.7% and 65.7% respectively (P<0.01).Conclusion The rate of negative transformation in the overlapping infection group is obviously higher than that in the contrast group.The titer may fall in some cases having no negative transformation.Interferences occur among hepatitis viruses and therefore,the replication of HBV can be in habited to some extent.
出处
《临沂医学专科学校学报》
2002年第5期349-351,共3页
Journal of Linyi Medical College
