摘要
本实验用大鼠 SAH 模型,对比研究丹参和钙离子拮抗剂 ND 对 SAH 后一系列病理生理反应的影响。实验发现 SAH 后可以引起 CVS,持续性 rCBF 降低,脑血管通透性增高。脑水肿和脑中LPO 升高,NPy 降低。丹参和 ND 均可以有效地防止 SAH 后脑血管通透性升高和脑水肿。在恢复rCBF 和防止 LPO 升高方面,丹参效果明显优于 ND。作者对丹参和 ND 防治 SAH 后 CVS 的机理作了初步探讨。
Intracranial subarachnoid hemorrhage(SAH)caninduce cerebral vasospasm(CVS),Serious CVSmay lead to a series pathophysiological responses,such as cerebral ischemia,edema,and infarction.The effect of Dan Shen(Salvia miltiorrhiza)andcalcium antagonist——nimodipine on CVS werestudied.Experimental SAH was performed in r(?)tsby inserting a tiny catheter subfrontally to Will'scircle.Fresh autologous blood was injected throughthis catheter.It was found the rCBF of bothhemisphere of the experimental rabbitg decreased,cerebral vascular permeability increased.Furthermore,brain edema appeared and cerebral lipoperpxides(LPO)increased.The PCO_2,PO_2 and BP were maintained at normal levels during the 6 hr ofSAH.Our results showed that CVS can be inducedby SAH.Dan Shen and nimodipine can prevent thechanges of cerebral vascular permeability and brainbulk effectively.The effect of Dan shen onincreasing rCBF and inhibiting LPO formation issignificantly better than nimodipine.The mechanismof Dan Shen and nimodipine in preventing CVS arealso disscused
出处
《中华神经外科杂志》
CSCD
北大核心
1991年第2期125-128,共4页
Chinese Journal of Neurosurgery
