摘要
目的 观察持续静滴异丙酚芬太尼复合液用于全凭静脉麻醉的临床效果。方法 80例ASAⅠ-Ⅱ级择期中上腹部手术病人,随机分为4组,Ⅰ组术中持续静滴异丙酚,间断静注芬太尼;Ⅱ、Ⅲ、Ⅳ组术中分别持续静满含芬太尼0.0002％、0.0003％、0.0004％的异丙酚芬太尼复合液。观察各组病例切皮前后的MAP及HR变化,并比较各组间的用药量及苏醒时间。结果MAP及HR在Ⅰ组病例切皮前后有明显变化(P<0.05),Ⅱ、Ⅲ、Ⅳ组病例切皮前后无明显变化(P>0.05);芬太尼用量各组间相近(P>0.05),异丙酚用量Ⅰ组较其他组大;苏醒时间Ⅰ组较其他组长。结论 持续静滴异丙酚芬太尼复合液用于全凭静脉麻醉,能维持有效的药物血药浓度,术中麻醉平稳,循环波动小,麻醉可控性强,苏醒时间短。
Objective To observe the clinical effect of propofol and fentanyl for continuous intravenous infusion used to intravenous anesthesia . Methods 80 ASA Ⅰ - Ⅱ patients of abdominal operation, were divided equally into 4 groups, group Ⅰ : continuous intravenous infusion of propofol and discontinuous fentanyl injection, groups Ⅱ ,Ⅲ ,Ⅳ : continuous intravenous infusion of propofol plus fentanyl 0.0002 % , 0.0003 % , 0. 0004% respectively. The variation of MAP and HR of every patient before cuting skin and after that, were observed and the quantity of drug and time of resuscitation were compared. Results Obvious variation of MAP and HR was found before cuting skin than after in group Ⅰ ( P < 0.05). In group Ⅱ , Ⅲ ,Ⅳ , no obvious variation was found. Quantity of fentanyl was similar, quantity of propofol in group Ⅰ was larger than other groups. Recovery time in group Ⅰ was longer than other groups. Conclusion Using this method, effective concentration of drug in blood can be maintained, fluctuation of blood circulation is small, regulation of anesthesia is easy and recovery time is short.
