摘要
用竞争性蛋白结合法和放射受体法观察了46例肾脏病患者血清维生素D代谢产物的变化。结果表明,各类肾脏病患者血清25-羟维生素D_3的含量均低于正常对照组,平均下降了41.2％(P<0.01),以尿毒症患者最低,表明肾脏病患者维生素D的营养状态是低下的。尿毒症和肾病综合征患者,血清1,25-二羟维生素D_3[1,25(OH)_2D_3]亦明显下降,分别比对照组降低了33.5％和42.4％(P<0.05),而慢性肾功能不全患者血清1,25(OH)_2D_3与肾功能不全的程度呈负相关。作者还对肾脏疾病维生素D代谢产物水平降低的机理进行了讨论。
Alterations of serum vitamin D metabolites were observed by competitive protein-binding assay and radioreceptor assay in 46 patients with renal disease inckding chronic renal failure (CRF), nephrotic syndrcme (NS) and nephritis. The results indicated that serum 25-hydroxy-vitamin D (25-OHD) level decreased 41.2% as compared with the control group (P<0.01) and the lowest was found in uremic patients. It showed that vitamin D level is low in renal disease. Meanwhile serum 1,25-dihydroxy-vitamin D [1,25(OH)2D3] levels in uremia and NS patients decreased 33.5^ and 42.2% respectively (P<0.05) as compared with control group; serum l,.25(OH)2D3levels in CRF patients were negatively correlated with the severity of renal failure. The mechanism of low vitamin D metabolites in renal disease was discussed.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1991年第2期84-86,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
维生素D
代谢产物
肾脏疾病
Vitamin D metabolites Renal failure, chronic Nephrotic syndrome
