摘要
目的:研究颅内血肿冲洗中应用亚低温冲洗液对神经功能、氧化应激的影响。方法:选择2014年8月～2017年11月期间在我院接受血肿抽吸的高血压脑出血患者,随机分为使用亚低温冲洗液的观察组、使用常温冲洗液的对照组。治疗前及治疗后72h抽取外周血,分离血清后测定神经损伤标志物、细胞因子、氧化应激介质的含量。结果:与对照组比较,观察组治疗后的血清神经元特异性烯醇化酶(NSE)、视锥蛋白样蛋白-1(VILIP-1)、神经胶质纤维酸性蛋白(GFAP)、神经肽Y(NPY)、血小板源性生长因子(PDGF)、血管内皮细胞(VEGF)、高迁移率族蛋白B1(HMGB1)、巨噬细胞移动抑制因子(MIF)、白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)、丙二醛(MDA)、8-OHdG、一氧化氮(NO)含量均明显降低,血清脑源性神经营养因子(BDNF)、胰岛素样生长因子-1(IGF-1)、总抗氧化力(TAOC)含量均明显升高(P<0.05)。结论:颅内血肿冲洗中应用亚低温冲洗液能够减轻神经功能损伤、改善神经营养状态并抑制氧化应激反应。
Objective： To investigate the effects of mild hypothermia irrigation fluid on nerve function and oxidative stress during intracranial hematoma irrigation. Methods： The patients with hypertensive cerebral hemorrhage who received hematoma aspiration in our hospital between August 2014 and November 2017 were enrolled and randomly divided into the observation group who received mild hypothermia irrigation fluid and the control group who received room temperature irrigation fluid. Before treatment and 72 hours after treatment, the contents of nerve injury markers, cytokines and oxidative stress mediators were measured after peripheral blood extraction and serum separation. Results： Compared with control group, serum neuron-specific enolase, visinin-like protein-1, glial fibrillary acidic protein, neuropeptide Y, platelet-derived growth factor, vascular endothelial growth factor, high mobility group protein B1, macrophage migration inhibitory factor, interleukin-1β, interleukin-10, malondialdehyde, 8-OHdG and nitric oxide contents of observation group were significantly lower whereas serum brain-derived neurotrophic factor, insulin-like growth factor-1 and total antioxidant capacity contents were significantly higher after treatment （ P 〈0.05）. Conclusions： The application of mild hypothermia irrigation fluid during intracranial hematoma irrigation can alleviate the nerve function injury, improve the neurotrophic status and inhibit the oxidative stress response.
作者
邓天国
DENG Tian-guo(Surgery Department,the Second People＇s Hospital of Mianning County,Sichuan 615602,China)
出处
《海南医学院学报》
CAS
2018年第22期1975-1978,1983,共5页
Journal of Hainan Medical University
基金
2005年四川省科技攻关计划基金项目(2005sz0171)~~
关键词
高血压脑出血
亚低温冲洗液
神经损伤
神经营养
氧化应激
Hypertensive cerebral hemorrhage
Mild hypothermia irrigation fluid
Nerve injury
Neurotrophy
Oxidative stress
