摘要
目的分析不良孕产患者外周血染色体异常检出率及异常核型分布的特点。方法按照常规G显带方法制备外周血淋巴细胞染色体,并对其核型进行数目和结构的分析。结果 4106例不良孕产患者中发现染色体异常核型297例,其中男性205例,女性92例。染色体结构异常63例,其中相互易位最多为36例(57.14%);染色体数目异常42例,其中性染色体三体最多为36例(85.71%);染色体多态性改变192例,其中Y染色体变异和D/G组染色体随体区变异最为多见,分别为77例和71例。结论不良孕产患者中染色体多态性发生率较高,并且染色体异常率男性明显高于女性。
Objective:To analyze the types and distribution characteristics of abnormal karyotypes of peripheral blood in patients with adverse pregnancy. Methods:According to the conventional preparation of peripheral blood lymphocyte chromosome G banding methods,and the number and structure of its karyotype are analyzed. Results:Among the 4106 cases of adverse pregnancy,297 cases of abnormal karyotype were found,including 205 males and 92 females.There were 63 cases of chromosomal structural abnormalities,among which 36 cases(57.14%)were translocated at most.The number of chromosomes was abnormal in 42 cases,of which the maximum number of sex chromosome trisomy was 36(85.71%). There were 192 cases of chromosomal polymorphism changes,among which,Y chromosome variation and D/G chromosome variation were the most common,77 cases and 71 cases respectively. Conclusions:The incidence of chromosomal polymorphism was higher in the patients with adverse pregnancy,and the rate of chromosomal abnormalities was significantly higher in males than in females.
作者
栗君
赵利伟
张伟
乔杰
李瑞云
LI Jun;ZHAO Liwei;ZHANG Wei;QIAO Jie;LI Rui-yun(King Med Diagnostics,Taiyuan,Shanxi,030000China)
出处
《中国优生与遗传杂志》
2018年第11期45-47,共3页
Chinese Journal of Birth Health & Heredity
关键词
不良孕产
染色体核型
染色体异常
Adverse pregnancy
Karyotyping
Chromosome abnormalities
