摘要
目的探讨唑来膦酸对重度骨质疏松性腰椎骨折行PKP术后视觉模拟评分(VAS)及骨密度的影响。方法选取重度骨质疏松性腰椎骨折患者78例,采用随机数字法将其分为对照组和研究组各39例。所有患者均行PKP手术,在此基础上,研究组予以唑来膦酸联合治疗,比较两组患者相关疗效指标。结果两组患者行PKP术后的VAS评分较术前均出现明显降低(P<0.01)。治疗后6个月,研究组VAS评分、sBAP及PINP水平均明显低于对照组(P<0.05);研究组Cobb角、骨密度值均显著高于对照组(P<0.05);研究组的ODI评分明显低于对照组,而AQL评分明显高于对照组(P<0.05);同时,研究组的再次骨折发生率明显低于对照组(P=0.03)。结论重度骨质疏松腰椎骨折PKP术后,服用唑来膦酸治疗可有效缓解疼痛,提高日常活动能力、生活质量,同时还可增加骨密度,降低骨转换率、减少远期骨折再发生率。
Objective To investigate the effect of zoledronic acid on visual analog scale （VAS）and bone mineral density（BMD） after PKP surgery in patients with severe osteoporotic lumbar fractures.Methods Seventy-eight patients with severe osteoporotic lumbar fractures were randomly divided intocontrol group and study group. All patients underwent PKP surgery. On this basis, the study group wastreated with zoledronic acid. The efficacy of the two groups was compared. Results After PKP surgery,the VAS scores of two groups were significantly lower than before surgery （P〈0.01）. At 6 months aftertreatment, the VAS score, sBAP and PINP levels in the study group were significantly lower than thosein the control group （P〈0.05）. The Cobb angle and BMD were significantly higher in the study groupthan in the control group （P〈0.05）. The ODI score of the study group was significantly lower than thatof the control group, and the AQL score of the study group was significantly higher than that of thecontrol group （P〈0.05）. At the same time, the incidence rate of re-fracture in the study group wassignificantly lower than that of the control group （P =0.03）. Conclusion After PKP in severeosteoporotic lumbar fractures, zoledronic acid treatment can effectively relieve pain, improve dailyactivity and quality of life, increase bone density, reduce bone turnover rate and reduce the incidenceof long-term fractures.
作者
郝川
覃裕
曹启辉
冯小波
彭雅女
吉杰男
HAO Chuan;QIN Yu;CAO Qi-hui;FENG Xiao-bo(Orthopaedic Hospital of Guizhou Province,Guiyang,Guizhou 550002,China)
出处
《颈腰痛杂志》
2018年第6期712-714,共3页
The Journal of Cervicodynia and Lumbodynia
