摘要
目的探讨纤溶酶注射液联合氯吡格雷治疗急性脑梗死的临床疗效和安全性。方法选取2015年5月至2017年12月本院收治的急性脑梗死患者202例,分为对照组与试验组,其中对照组(104例)仅给予氯吡格雷抗血小板治疗,试验组(98例)在氯吡格雷治疗基础上加用纤溶酶注射液,比较两组治疗前和治疗后的神经功能缺损评分以及出血事件发生率。结果两组患者治疗后神经功能缺损评分均显著低于治疗前(P <0.05);试验组患者治疗后的神经功能缺损评分(2.5±1.2)分低于对照组(4.7±1.4)分(t=11.848,P <0.05);试验组的基本治愈率、进步率与对照组相比差异无统计学意义(P> 0.05),而显著进步率39.8%和总有效率91.83%明显高于对照组(23.08%,71.15%,χ~2=6.572,χ~2=14.132,P均<0.05);试验组与对照组比较,治疗后的出血事件发生率差异无统计学意义(P> 0.05)。结论纤溶酶注射液联合氯吡格雷治疗急性脑梗死疗效显著,神经功能缺损状态改善明显,并且安全性好,不增加出血风险。
Objective To observe the clinical efficacy and safety of plasmin injection combined with clopidogrel in the treatment of acute cerebral infarction. Methods A total of 202 patients with acute cerebral infarction who were admitted to the hospital from May 2015 to February 2017 were selected, and were then divided into the control group and the experimental group.The control group （104 patients） received clopidogrel antiplatelet therapy alone, and the experimental group （98 patients） received plasmin injection based on the clopidogrel treatment.The neurological deficit scores before and after treatment and the incidence of bleeding events were compared. Results The neurological deficit scores of the two groups after treatment were significantly lower than those before treatment （P〈0.05）. The neurological deficit scores of the experimental group（2.5±1.2） were lower than those of the control group（4.7±1.4） after treatment （t=11.848,P 〈 0.05）; There was no significant difference of the basic cure rate and the improvement rate between the experimental group and the control group （P〉0.05）, and the significant improvement rate and total effective rate of the experimental group were significantly higher than those of the control group （39.8%, 91.83% v.s. 23.08%, 71.15%, χ^2=6.572, 14.132, P 〈 0.05）. The incidence of bleeding events after treatment was not significant in the experimental group compared with those in the control group （P〉0.05）. Conclusion Plasmin injection combined with clopidogrel is effective in the treatment of acute cerebral infarction. It could improve the neurological deficit state significantly and ensure safety without increasing the risk of bleeding.
作者
余聪
李永坤
YU Cong;LI Yong-kun(Internal Medicine,Fujian Provincial Hospital South Hospital,Fuzhou 35001,China;Department of Neurology,Fujian Provincial Hospital,Fuzhou 35001,China)
出处
《创伤与急诊电子杂志》
2018年第2期69-72,共4页
Journal of Trauma and Emergency(Electronic Version)
基金
福建省卫生系统中青年骨干人才培养项目(NO.2015-ZQN-ZD-06)
福建省卫计委医学创新课题(NO.2014-CX-1)
关键词
急性脑梗死
纤溶酶
氯吡格雷
疗效分析
Acute cerebral infarction
Plasmin
Clopidogrel
Efficacy analysis
