摘要
目的：探讨中西医结合治疗肝郁脾虚型功能性消化不良的机制及对焦虑抑郁评分影响。方法：纳入150例肝郁脾虚型功能性消化不良患者,采用随机数字表法分为治疗组和对照组各75例,对照组给予多潘立酮和路优泰治疗,治疗组在其基础上给予疏肝解郁、辛开苦降中药治疗,4周为1个疗程。观察中医证候量化分级、焦虑自评量表（SAS）评分、抑郁自评量表（SDS）评分及血浆胃动素（MTL）、胃泌素（GAS）等指标积分变化,并进行临床疗效对比。结果：两组组内证候量化积分比较,差异均有统计学意义（P〈0.05）;治疗后,治疗组痞满不适、早饱、嗳气呃逆、口苦或黏、口干舌燥较对照组相比,差异均有统计学意义（P〈0.05）,腹胀、口渴不欲饮、大便糖稀较对照组比较,差异无统计学意义（P〉0.05）;两组治疗后血浆MTL、GAS水平与治疗前比较差异均有统计学意义（P〈0.05）,且治疗组均高于对照组（P〈0.05）;两组治疗后SAS、SDS评分与治疗前比较差异均有统计学意义（P〈0.05）,且治疗组评分均低于对照组（P〈0.05）;治疗1疗程后,治疗组总有效率94.7%,对照组86.7%,差异有统计学意义（P〈0.05）。结论：中西医结合治疗能够改善肝郁脾虚型功能性消化不良的临床证候,并调节胃肠激素及SAS、SDS水平,为临床治疗提供安全、有效的循证医学依据。
Objectives：To study the underlying mechanism of functional dyspepsia of liver stagnation and spleen deficiency treated with integrated Chinese and western medicine,and the effect of anxiety and de- pression scores. Methods：One hundred and fifty patients with functional dyspepsia of liver stagnation and spleen deficiency were divided into the treatment group and control group by the random number table method,75 patients in each group. The control group was given polyperridone and luyote while the treatment group was also given Chinese herbal medicinals for soothing liver and resolving constraint,acridity opening and bitterness downbearing,4 weeks as 1 course. Traditional Chinese medicine（TCM） symptom scores,self- rating anxiety scale（SAS） score and self-rating depression scale（SDS） score were determined,plasma levels of motilin（MTL） and gastrin（GAS） and so on were also measured,and the clinical efficacy between two groups was compared. Results：After the treatment,TCM symptom scores changed in the treatment group and control group,with statistical significance（P〈0.05）,and on the pi and full sensation,early satietv.belchina.hiccup, mouth bitter or sticky, dry mouth and tongue, the treatment group was better than the control group,with statistical significance （P〈 0.05）, while there was no significant difference on abdominal distension,thirst without a desire to drink, and loose stool between two groups（P〉0.05）;there were significant differences on plasma levels of MTL and GAS between the two groups （P〈 0.05 ） , and the levels of MTL and GAS in the treatment group were higher than those in the control group（P〈0.05）;there were significant changes on SAS and SDS scores in both two groups（P〈0.05）,and the SAS and SDS scores in the treatment group were lower than those in the control group（P〈0.05）;after 1 course of treatment,the total effective rates in the treatment group and control group were 94.7% and 86.7%,respectively,with statistical significance. Conclusions：Integrated Chinese and western medicine can improve clinical symptoms in functional dyspepsia of liver and spleen deficiency,regulate gastrointestinal hormones and the level of SAS and SDS,and provide a safe and effective evidence-based medical basis for clinical treatment.
作者
张学虹
雷华斌
王成凯
毛娅
ZHANG Xuehong;LEI Huabin;WANG Chengkai;MAO Ya(South Division,Tongehuan People＇s Hospital,Tongchuan,727000,China;Sun Simiao Hospital,Beijing U-niversity of Chinese Medicine,Tongchuan 727000,China;Ankang Hospital of Traditional Chinese Medicine,Ankang 725000,China)
出处
《山东中医杂志》
2018年第11期891-895,共5页
Shandong Journal of Traditional Chinese Medicine
基金
陕西省中医药管理局项目(编号:2017-LCMS034)
关键词
功能性消化不良
肝郁脾虚证
中西医有机结合
焦虑抑郁评分
临床疗效
functional dyspepsia
liver stagnation and spleen deficiency syndrome
integrated Chinese andwestern medicine
anxiety and depression scores
clinical efficacy
