摘要
60例肾移植术后的108份GsA血样用特异性单克隆(MAFPIA)和非特异性多克隆荧光免疫偏振分析法(PAFPIA)进行测定。结合肝脏功能与术后时间,观察药物浓度的变化。两种检测方法之间有线性关系(r=0.8926),二者的测得值有非常显著性差异。肝功能异常的患者PAFPIA/MAFPIA比值以及回归曲线参数与肝功能正常的患者相比有明显差异,表明肝功能异常的患者GsA的代谢产物在体内蓄积而使得检测结果偏高。术后时间对药物浓度变化有一定的作用。术后近期(10d内)与术后(3～7周)服用等同剂量的GsA,血药浓度有明显差异。说明对于肾移植术后服用CsA的患者,应持续、定期地进行药物浓度的监测。
108 whole blood specimens from 60 renal transplant recipients receiving cyclosporin A (CsA) have been assayed for CsA level with the specific monoclonal antibody (MAFPIA) and nonspecific polyclonal antibody fluorescence polarization immunoassay (PAFPIA). Linear regression analysis showed that there was a relationship between MAFPIA and PAFPIA (r = 0.8926) and PAFPIA/MAFPIA value and linear regression curve parameters of patients with impaired and normal hepatic function differed greatly. The time elapsed after transplantation could be a factor influencing the GsA blood concentration. It was pointed out that regular and periodic blood CsA monitoring after renal transplantation should be adopted as a routine.
出处
《空军总医院学报》
1993年第3期129-132,共4页
Journal of General Hospital of Air Force,PLA
