摘要
目的探讨糖尿病视网膜病变(DR)与免疫球蛋白G (IgG)N-糖基化的相关性,为疾病的发生发展提供依据。方法将纳入的2型糖尿病患者以是否患有DR分为病例组和对照组,比较两组IgG N-糖基化水平,通过二分类logistic模型校正其他协变量。结果直接测量的糖基峰中,GP4、GP6、GP17和GP19在病例组水平较高,而GP15、GP16、GP18和GP21在对照组含量较高(P<0.05);在校正年龄、性别等其他协变量后,代表唾液酸化的10种衍生结构差异均有统计学意义(P<0.05)。结论 IgG N-糖基化的唾液酸化与DR的发生发展有相关性。
Objective To explore the association between diabetic retinopathy（DR）and immunoglobulin G（IgG）N-glycosylation,and to provide basis for disease control. Methods Type 2 diabetes mellitus（T2 DM）patients were divided into case group（with DR）and control group（without DR）.The levels of IgG N-glycosylation were compared between two groups and the other covariates were adjusted by dichotomous logistic model. Results Among the directed measured glycans,the levels of GP4,GP6,GP17 and GP19 were higher in case group,while the levels of GP15,GP16,GP18 and GP21 were higher in control group（P〈0.05）.After adjusting for other covariates by age and gender,the differences of ten derived glycans representing sialylation were significant（P〈0.05）. Conclusions There is a positive correlation between IgG N-glycosylated sialylation and the development of DR.
作者
孙扬
李琪欢
田思佳
张杰
王友信
平昭
王嵬
郭秀花
SUN Yang;LI Qi-huan;TIAN Si-jia;ZHANG Jie;WANG You-xin;PING Zhao;WANG Wei;GUO Xiu-hua(Department of Epidemiology and Health Statistics,School of Public Health,Capital Medical University,Beijing 100069,China)
出处
《中国预防医学杂志》
CAS
CSCD
2018年第10期734-737,共4页
Chinese Preventive Medicine
基金
国家自然科学基金重点项目(8153000381)
