摘要
目的:分析胆囊癌组织中β-catenin和ILK的表达及其与临床病理参数的相关性。方法:选择2013年4月至2016年5月在本院进行胆囊相关手术的患者病例组织标本75例,根据病理组织检查结果,有47例为胆囊癌,胆囊瘤性息肉标本13例,慢性胆囊炎标本15例,采用免疫组化法对各组患者组织中β-catenin和ILK的表达水平进行测定。结果:胆囊癌癌变组织中ILK,β-catenin表达水平显著高于胆囊瘤性息肉和慢性胆囊炎,差异有统计学意义(P<0.05)。肿瘤直径≥2cm患者ILK,β-catenin阳性率均高于肿瘤直径<2cm患者,其中β-catenin阳性率差异有统计学意义(P<0.05)。不同病理分化程度患者ILK,β-catenin阳性率差异显著,从高至低依次为高分化、中分化、低分化患者。浆膜浸润患者ILK,β-catenin阳性率高于非浆膜浸润患者,差异有统计学意义(P<0.05)。淋巴结转移患者ILK,β-catenin阳性率高于无淋巴结转移患者,统计学分析表明差异显著(P <0.05)。胆囊癌组织中LLK阳性率与β-catenin阳性率呈显著正相关,差异有统计学意义(P<0.05)。结论:胆囊癌组织中β-catenin和ILK的表达阳性率明显升高,且其表达水平升高可能预示着患者浆膜浸润、淋巴结转移风险的增加,同时β-catenin和ILK的表达水平呈显著正相关。
Objective： To analyze the expression of β-catenin and ILK in gallbladder carcinoma and itscorrelation with clinicopathologic parameters. Methods： 75 cases of cholecystitis associated with cholecystitisfrom April 2013 to May 2016 were selected. According to the results of pathological examination, 47 caseswere gallbladder carcinoma, 13 cases were cystic polyps, and 15 cases were chronic cholecystitis. The expression levels of β-catenin and ILK were measured. Results： The expression of ILK, β -catenin in gallbladdercarcinoma was significantly higher than that in cystic polyps and chronic cholecystitis （P〈0.05）. The positiverates of ILK and β-catenin in patients with tumor diameter ≥ 2cm were higher than those in patients withtumor diameter 〈 2cm, and the difference of positive rate of β -catenin was statistically significant （P〈0.05）.The positive rates of ILK and β -catenin in patients with different pathological differentiation degrees were significantly different. The positive rates of ILK and β -catenin from high to low were high differentiation, middledifferentiation and low differentiation. The positive rate of ILK and β -catenin in serous infiltration patients washigher than that in non-serous infiltration patients （P〈0.05）. The positive rate of ILK and β -catenin in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis（P〈0.05）. There was a significant positive correlation between the positive rate of LLK and β -catenin ingallbladder carcinoma （P〈0.05）. Conclusion： The positive rates of β -catenin and ILK in gallbladder carcinoma tissues are significantly increased, and the increased expression level of β -catenin and ILK may indicate the increase of invasion and lymph node metastasis risk, and the expression of β -catenin and ILK is positively correlated with the expression of β -catenin in gallbladder carcinoma.
作者
徐丹
许海周
XU Dan(Rugao People＇s Hospital,Jiangsu Rugao 226500,China)
出处
《河北医学》
CAS
2018年第11期1790-1793,共4页
Hebei Medicine
基金
江苏省南通市科技计划项目
(编号:GJZ16035)
